Protein - Calorie malnutrition does not predict subtle vitamin K depletion in hospitalized patients

Aminah Jatoi, C. Lennon, M. O'Brien, S. L. Booth, J. Sadowski, J. B. Mason

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Recent studies suggest that subtle vitamin K depletion has far-reaching consequences. As this entity is not associated with prothrombin time elevation, it is important to determine whether alternate methods can help identify it. We investigated subtle vitamin K depletion in a hospital setting and determined whether protein-calorie malnutrition predicts its presence. Design, setting, subjects: Using a high-pressure liquid chromatography (HPLC) assay of plasma phylloquinone and a food frequency questionnaire for phylloquinone intake, we examined the phylloquinone status of 27 hospitalized patients with normal coagulation parameters, no liver disease, and no recent warfarin use. We assessed protein-calorie nutritional status with Reilly's criteria and anthropometrics. Results: 51% of patients (95% Cl = 31% to 70%) had evidence of subtle vitamin K depletion as defined by a subnormal plasma phylloquinone concentration. Patients whose phylloquinone intake was less than the Recommended Daily Allowance (RDA) over the preceding year had lower plasma phylloquinone concentrations when compared to other patients: median (range) 0.106 nmol/l (0.022-0.461) versus 0.301 nmol/l (0.067-3.928), respectively (P = 0.023). Plasma phylloquinone concentrations were no different, however, between well-nourished and malnourished patients: median (range) 0.245 nmol/l (0.022-0.522) versus 0.188 nmol/l (0.067-3.928), respectively (P = 0.782). Conclusions: Subtle vitamin K depletion is common among hospitalized patients and protein-calorie malnutrition does not predict its presence.

Original languageEnglish (US)
Pages (from-to)934-937
Number of pages4
JournalEuropean Journal of Clinical Nutrition
Volume52
Issue number12
StatePublished - 1998

Fingerprint

Vitamin K 1
phylloquinone
Protein-Energy Malnutrition
vitamin K
protein energy malnutrition
Vitamin K
warfarin
Recommended Dietary Allowances
prothrombin
Prothrombin Time
food frequency questionnaires
liver diseases
Warfarin
coagulation
Nutritional Status
nutritional status
Liver Diseases
high performance liquid chromatography
High Pressure Liquid Chromatography
Food

Keywords

  • Phylloquinone
  • Protein-calorie malnutrition
  • Vitamin K

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Jatoi, A., Lennon, C., O'Brien, M., Booth, S. L., Sadowski, J., & Mason, J. B. (1998). Protein - Calorie malnutrition does not predict subtle vitamin K depletion in hospitalized patients. European Journal of Clinical Nutrition, 52(12), 934-937.

Protein - Calorie malnutrition does not predict subtle vitamin K depletion in hospitalized patients. / Jatoi, Aminah; Lennon, C.; O'Brien, M.; Booth, S. L.; Sadowski, J.; Mason, J. B.

In: European Journal of Clinical Nutrition, Vol. 52, No. 12, 1998, p. 934-937.

Research output: Contribution to journalArticle

Jatoi, A, Lennon, C, O'Brien, M, Booth, SL, Sadowski, J & Mason, JB 1998, 'Protein - Calorie malnutrition does not predict subtle vitamin K depletion in hospitalized patients', European Journal of Clinical Nutrition, vol. 52, no. 12, pp. 934-937.
Jatoi, Aminah ; Lennon, C. ; O'Brien, M. ; Booth, S. L. ; Sadowski, J. ; Mason, J. B. / Protein - Calorie malnutrition does not predict subtle vitamin K depletion in hospitalized patients. In: European Journal of Clinical Nutrition. 1998 ; Vol. 52, No. 12. pp. 934-937.
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AU - Jatoi, Aminah

AU - Lennon, C.

AU - O'Brien, M.

AU - Booth, S. L.

AU - Sadowski, J.

AU - Mason, J. B.

PY - 1998

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N2 - Objective: Recent studies suggest that subtle vitamin K depletion has far-reaching consequences. As this entity is not associated with prothrombin time elevation, it is important to determine whether alternate methods can help identify it. We investigated subtle vitamin K depletion in a hospital setting and determined whether protein-calorie malnutrition predicts its presence. Design, setting, subjects: Using a high-pressure liquid chromatography (HPLC) assay of plasma phylloquinone and a food frequency questionnaire for phylloquinone intake, we examined the phylloquinone status of 27 hospitalized patients with normal coagulation parameters, no liver disease, and no recent warfarin use. We assessed protein-calorie nutritional status with Reilly's criteria and anthropometrics. Results: 51% of patients (95% Cl = 31% to 70%) had evidence of subtle vitamin K depletion as defined by a subnormal plasma phylloquinone concentration. Patients whose phylloquinone intake was less than the Recommended Daily Allowance (RDA) over the preceding year had lower plasma phylloquinone concentrations when compared to other patients: median (range) 0.106 nmol/l (0.022-0.461) versus 0.301 nmol/l (0.067-3.928), respectively (P = 0.023). Plasma phylloquinone concentrations were no different, however, between well-nourished and malnourished patients: median (range) 0.245 nmol/l (0.022-0.522) versus 0.188 nmol/l (0.067-3.928), respectively (P = 0.782). Conclusions: Subtle vitamin K depletion is common among hospitalized patients and protein-calorie malnutrition does not predict its presence.

AB - Objective: Recent studies suggest that subtle vitamin K depletion has far-reaching consequences. As this entity is not associated with prothrombin time elevation, it is important to determine whether alternate methods can help identify it. We investigated subtle vitamin K depletion in a hospital setting and determined whether protein-calorie malnutrition predicts its presence. Design, setting, subjects: Using a high-pressure liquid chromatography (HPLC) assay of plasma phylloquinone and a food frequency questionnaire for phylloquinone intake, we examined the phylloquinone status of 27 hospitalized patients with normal coagulation parameters, no liver disease, and no recent warfarin use. We assessed protein-calorie nutritional status with Reilly's criteria and anthropometrics. Results: 51% of patients (95% Cl = 31% to 70%) had evidence of subtle vitamin K depletion as defined by a subnormal plasma phylloquinone concentration. Patients whose phylloquinone intake was less than the Recommended Daily Allowance (RDA) over the preceding year had lower plasma phylloquinone concentrations when compared to other patients: median (range) 0.106 nmol/l (0.022-0.461) versus 0.301 nmol/l (0.067-3.928), respectively (P = 0.023). Plasma phylloquinone concentrations were no different, however, between well-nourished and malnourished patients: median (range) 0.245 nmol/l (0.022-0.522) versus 0.188 nmol/l (0.067-3.928), respectively (P = 0.782). Conclusions: Subtle vitamin K depletion is common among hospitalized patients and protein-calorie malnutrition does not predict its presence.

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