Protective effects of intestinal trefoil factor (ITF) on gastric mucosal epithelium through activation of extracellular signal-regulated kinase 1/2 (ERK1/2)

Jinfeng Lin, Zhaorui Sun, Wei Zhang, Hongmei Liu, Danbing Shao, Yi Ren, Yanfang Wen, Liping Cao, Joy Wolfram, Zhizhou Yang, Shinan Nie

Research output: Contribution to journalArticle

8 Scopus citations


The rapid repair of gastric mucosa is critical upon exposure to injurious agents. Intestinal trefoil factor (ITF) is a member of the trefoil factor family domain peptides, which play an important role in the cytoprotection of gastric epithelium. However, the underlying molecular mechanisms that are responsible for ITF-induced gastric epithelial repair remain unclear. In the present study, we demonstrate that ITF enhances the proliferation and migration of GES-1 gastric endothelial cells in a dose- and time-dependent manner through the activation of extracellular signal-regulated kinase 1/2 (ERK1/2). Furthermore, the ITF-mediated protection of GES-1 cells from a NS398 (nonsteroidal anti-inflammatory drug) was dependent on the ERK1/2 signaling pathway. Taken together, the results provide a mechanistic explanation for ITF-mediated protection of gastric epithelial mucosa cells, suggesting that activation of the ERK1/2 signaling pathway may provide a new therapeutic strategy for repairing gastric injury.

Original languageEnglish (US)
Pages (from-to)263-270
Number of pages8
JournalMolecular and Cellular Biochemistry
Issue number1-2
StatePublished - Jun 18 2015
Externally publishedYes



  • Cytoprotection
  • ERK1/2 signaling pathway
  • Gastric mucosal epithelium
  • Intestinal trefoil factor

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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