Protective effect of methanol extract of Uncaria rhynchophylla against excitotoxicity induced by N-methyl-D-aspartate in rat hippocampus

Jongseok Lee, Dongwook Son, Pyeongjae Lee, Dae Keun Kim, Min Chul Shin, Mi Hyeon Jang, Chang Ju Kim, Yong Sik Kim, Sun Yeou Kim, Hocheol Kim

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Uncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-D-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. In the patch clamp study, Uncaria rhynchophylla significantly inhibited NMDA receptor-activated ion current in acutely dissociated hippocampal CA1 neurons. These results indicate that Uncaria rhynchophylla offers protection against NMDA-induced neuronal injury and inhibitory action on NMDA receptor-mediated ion current may be a mechanism behind the neuroprotective effect of Uncaria rhynchophylla.

Original languageEnglish (US)
Pages (from-to)70-73
Number of pages4
JournalJournal Pharmacological Sciences
Volume92
Issue number1
DOIs
StatePublished - May 1 2003

Keywords

  • Hippocampus
  • N-methyl-D-aspartate
  • Uncaria rhynchophylla

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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