Protective effect of methanol extract of Uncaria rhynchophylla against excitotoxicity induced by N-methyl-D-aspartate in rat hippocampus

Jongseok Lee; Dongwook Son; Pyeongjae Lee; Dae Keun Kim; Min Chul Shin; Mi Hyeon Jang; Chang Ju Kim; Yong Sik Kim; Sun Yeou Kim; Hocheol Kim

doi:10.1254/jphs.92.70

Protective effect of methanol extract of Uncaria rhynchophylla against excitotoxicity induced by N-methyl-D-aspartate in rat hippocampus

Jongseok Lee, Dongwook Son, Pyeongjae Lee, Dae Keun Kim, Min Chul Shin, Mi Hyeon Jang, Chang Ju Kim, Yong Sik Kim, Sun Yeou Kim, Hocheol Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Uncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-D-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. In the patch clamp study, Uncaria rhynchophylla significantly inhibited NMDA receptor-activated ion current in acutely dissociated hippocampal CA1 neurons. These results indicate that Uncaria rhynchophylla offers protection against NMDA-induced neuronal injury and inhibitory action on NMDA receptor-mediated ion current may be a mechanism behind the neuroprotective effect of Uncaria rhynchophylla.

Original language	English (US)
Pages (from-to)	70-73
Number of pages	4
Journal	Journal Pharmacological Sciences
Volume	92
Issue number	1
DOIs	https://doi.org/10.1254/jphs.92.70
State	Published - May 1 2003

Keywords

Hippocampus
N-methyl-D-aspartate
Uncaria rhynchophylla

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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title = "Protective effect of methanol extract of Uncaria rhynchophylla against excitotoxicity induced by N-methyl-D-aspartate in rat hippocampus",

abstract = "Uncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-D-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. In the patch clamp study, Uncaria rhynchophylla significantly inhibited NMDA receptor-activated ion current in acutely dissociated hippocampal CA1 neurons. These results indicate that Uncaria rhynchophylla offers protection against NMDA-induced neuronal injury and inhibitory action on NMDA receptor-mediated ion current may be a mechanism behind the neuroprotective effect of Uncaria rhynchophylla.",

keywords = "Hippocampus, N-methyl-D-aspartate, Uncaria rhynchophylla",

author = "Jongseok Lee and Dongwook Son and Pyeongjae Lee and Kim, {Dae Keun} and Shin, {Min Chul} and Jang, {Mi Hyeon} and Kim, {Chang Ju} and Kim, {Yong Sik} and Kim, {Sun Yeou} and Hocheol Kim",

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doi = "10.1254/jphs.92.70",

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AU - Lee, Jongseok

AU - Son, Dongwook

AU - Lee, Pyeongjae

AU - Kim, Dae Keun

AU - Shin, Min Chul

AU - Jang, Mi Hyeon

AU - Kim, Chang Ju

AU - Kim, Yong Sik

AU - Kim, Sun Yeou

AU - Kim, Hocheol

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Uncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-D-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. In the patch clamp study, Uncaria rhynchophylla significantly inhibited NMDA receptor-activated ion current in acutely dissociated hippocampal CA1 neurons. These results indicate that Uncaria rhynchophylla offers protection against NMDA-induced neuronal injury and inhibitory action on NMDA receptor-mediated ion current may be a mechanism behind the neuroprotective effect of Uncaria rhynchophylla.

AB - Uncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-D-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. In the patch clamp study, Uncaria rhynchophylla significantly inhibited NMDA receptor-activated ion current in acutely dissociated hippocampal CA1 neurons. These results indicate that Uncaria rhynchophylla offers protection against NMDA-induced neuronal injury and inhibitory action on NMDA receptor-mediated ion current may be a mechanism behind the neuroprotective effect of Uncaria rhynchophylla.

KW - Hippocampus

KW - N-methyl-D-aspartate

KW - Uncaria rhynchophylla

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Protective effect of methanol extract of Uncaria rhynchophylla against excitotoxicity induced by N-methyl-D-aspartate in rat hippocampus

Abstract

Keywords

ASJC Scopus subject areas

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