Abstract
BACKGROUND AND PURPOSE - : Reversal of anticoagulation with protamine might predispose to a higher risk of stroke in patients with carotid stenting. We evaluated a national, multihospital patient database to examine the risk of stroke in patients with carotid stenting receiving protamine compared with those who did not. METHODS - : The Premier Perspective database was used to identify patients who were electively hospitalized for carotid stenting from 2006 through 2011. The incidence of in-hospital mortality and morbidity was compared between patients who did and did not receive protamine after propensity score adjustment via 1:1 matching to reduce selection bias. RESULTS - : Of 6664 patients with carotid stenting treated at 193 hospitals, 556 (8%) received protamine on the day of the procedure. After matching by propensity score, patients who received protamine had a similar likelihood of stroke or transient ischemic attack (P=0.77), in-hospital mortality (P=0.12), discharge to long-term care (P=0.15), and access site complications (P=0.90) as compared with patients who did not receive protamine. CONCLUSIONS - : Protamine administration is not associated with additional risk of adverse events after carotid stenting.
Original language | English (US) |
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Pages (from-to) | 2028-2030 |
Number of pages | 3 |
Journal | Stroke |
Volume | 44 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2013 |
Keywords
- carotid stenosis
- carotid stenting
- coagulation
- outcomes research
- protamine
ASJC Scopus subject areas
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
- Advanced and Specialized Nursing