Prosthetic hip replacement for pathologic or impending pathologic fractures in myeloma

Panayiotis J. Papagelopoulos, Evanthia Galanis, Philip R. Greipp, Franklin H. Sim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The authors retrospectively reviewed 53 hip replacements performed in 50 patients (mean age, 65 years) for plasmacytoma (four lesions) or multiple myeloma (49 lesions) of the hip region. Perioperatively, 49 patients received chemotherapy. Twenty-four hip lesions had radiation therapy. Within a mean followup period of 32.6 months, 15 (28%) complications occurred. Late deep infection, dislocation, and aseptic loosening with medial migration of the acetabular component occurred in one patient each. Three patients died during the first postoperative month. All of the remaining patients postoperatively regained their previous ambulatory status; hip pain relief was achieved in 98% of patients. At the time of the latest followup evaluation, 84% of the patients had died (median survival time, 18 months) and 16% were still alive (median survival time, 76 months). Patients with plasmacytoma had longer survival than did patients with multiple myeloma (median survival, 6.3 years versus 18 months, respectively). No significant association was found between patient survival and the stage of disease at diagnosis, age, gender, type or location of the myeloma lesion, or the type of implant used. Because of the relatively long survival time, prosthetic replacement is indicated for extensive hip lesions in patients with plasmacytoma or multiple myeloma.

Original languageEnglish (US)
Pages (from-to)192-205
Number of pages14
JournalClinical Orthopaedics and Related Research
Issue number341
StatePublished - Aug 1997

Fingerprint

Spontaneous Fractures
Hip
Plasmacytoma
Survival
Multiple Myeloma
Radiotherapy

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Prosthetic hip replacement for pathologic or impending pathologic fractures in myeloma. / Papagelopoulos, Panayiotis J.; Galanis, Evanthia; Greipp, Philip R.; Sim, Franklin H.

In: Clinical Orthopaedics and Related Research, No. 341, 08.1997, p. 192-205.

Research output: Contribution to journalArticle

Papagelopoulos, Panayiotis J. ; Galanis, Evanthia ; Greipp, Philip R. ; Sim, Franklin H. / Prosthetic hip replacement for pathologic or impending pathologic fractures in myeloma. In: Clinical Orthopaedics and Related Research. 1997 ; No. 341. pp. 192-205.
@article{eb6de6c679134bfd973e8fe676444ac1,
title = "Prosthetic hip replacement for pathologic or impending pathologic fractures in myeloma",
abstract = "The authors retrospectively reviewed 53 hip replacements performed in 50 patients (mean age, 65 years) for plasmacytoma (four lesions) or multiple myeloma (49 lesions) of the hip region. Perioperatively, 49 patients received chemotherapy. Twenty-four hip lesions had radiation therapy. Within a mean followup period of 32.6 months, 15 (28{\%}) complications occurred. Late deep infection, dislocation, and aseptic loosening with medial migration of the acetabular component occurred in one patient each. Three patients died during the first postoperative month. All of the remaining patients postoperatively regained their previous ambulatory status; hip pain relief was achieved in 98{\%} of patients. At the time of the latest followup evaluation, 84{\%} of the patients had died (median survival time, 18 months) and 16{\%} were still alive (median survival time, 76 months). Patients with plasmacytoma had longer survival than did patients with multiple myeloma (median survival, 6.3 years versus 18 months, respectively). No significant association was found between patient survival and the stage of disease at diagnosis, age, gender, type or location of the myeloma lesion, or the type of implant used. Because of the relatively long survival time, prosthetic replacement is indicated for extensive hip lesions in patients with plasmacytoma or multiple myeloma.",
author = "Papagelopoulos, {Panayiotis J.} and Evanthia Galanis and Greipp, {Philip R.} and Sim, {Franklin H.}",
year = "1997",
month = "8",
language = "English (US)",
pages = "192--205",
journal = "Clinical Orthopaedics and Related Research",
issn = "0009-921X",
publisher = "Springer New York",
number = "341",

}

TY - JOUR

T1 - Prosthetic hip replacement for pathologic or impending pathologic fractures in myeloma

AU - Papagelopoulos, Panayiotis J.

AU - Galanis, Evanthia

AU - Greipp, Philip R.

AU - Sim, Franklin H.

PY - 1997/8

Y1 - 1997/8

N2 - The authors retrospectively reviewed 53 hip replacements performed in 50 patients (mean age, 65 years) for plasmacytoma (four lesions) or multiple myeloma (49 lesions) of the hip region. Perioperatively, 49 patients received chemotherapy. Twenty-four hip lesions had radiation therapy. Within a mean followup period of 32.6 months, 15 (28%) complications occurred. Late deep infection, dislocation, and aseptic loosening with medial migration of the acetabular component occurred in one patient each. Three patients died during the first postoperative month. All of the remaining patients postoperatively regained their previous ambulatory status; hip pain relief was achieved in 98% of patients. At the time of the latest followup evaluation, 84% of the patients had died (median survival time, 18 months) and 16% were still alive (median survival time, 76 months). Patients with plasmacytoma had longer survival than did patients with multiple myeloma (median survival, 6.3 years versus 18 months, respectively). No significant association was found between patient survival and the stage of disease at diagnosis, age, gender, type or location of the myeloma lesion, or the type of implant used. Because of the relatively long survival time, prosthetic replacement is indicated for extensive hip lesions in patients with plasmacytoma or multiple myeloma.

AB - The authors retrospectively reviewed 53 hip replacements performed in 50 patients (mean age, 65 years) for plasmacytoma (four lesions) or multiple myeloma (49 lesions) of the hip region. Perioperatively, 49 patients received chemotherapy. Twenty-four hip lesions had radiation therapy. Within a mean followup period of 32.6 months, 15 (28%) complications occurred. Late deep infection, dislocation, and aseptic loosening with medial migration of the acetabular component occurred in one patient each. Three patients died during the first postoperative month. All of the remaining patients postoperatively regained their previous ambulatory status; hip pain relief was achieved in 98% of patients. At the time of the latest followup evaluation, 84% of the patients had died (median survival time, 18 months) and 16% were still alive (median survival time, 76 months). Patients with plasmacytoma had longer survival than did patients with multiple myeloma (median survival, 6.3 years versus 18 months, respectively). No significant association was found between patient survival and the stage of disease at diagnosis, age, gender, type or location of the myeloma lesion, or the type of implant used. Because of the relatively long survival time, prosthetic replacement is indicated for extensive hip lesions in patients with plasmacytoma or multiple myeloma.

UR - http://www.scopus.com/inward/record.url?scp=0030761548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030761548&partnerID=8YFLogxK

M3 - Article

C2 - 9269174

AN - SCOPUS:0030761548

SP - 192

EP - 205

JO - Clinical Orthopaedics and Related Research

JF - Clinical Orthopaedics and Related Research

SN - 0009-921X

IS - 341

ER -