Prostatitis as a risk factor for prostate cancer

Rosebud O Roberts, Erik J. Bergstralh, Sarah E. Bass, Michael M. Lieber, Steven J. Jacobsen

Research output: Contribution to journalArticle

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Abstract

Background: The association of infection or inflammation of the prostate with prostate cancer has been suggested but not established. This study was undertaken to investigate this association. Methods: Cases were Olmsted County, Minnesota, residents with histologically proven prostate cancer diagnosed between January 1980 and December 1996. Cases (n = 409) were each matched to 2 control subjects (n = 803) on age at diagnosis of prostate cancer, residency in Olmsted County, and duration of the community medical record. The medical record of each subject was reviewed for a history of acute or chronic bacterial prostatitis or chronic pelvic pain syndrome (inflammatory type). Results: The relative odds of prostate cancer were elevated in men with history of any type of prostatitis (odds ratio [OR] = 1.7; 95% confidence interval [CI] = 1.1-2.6) or acute prostatitis (2.5; 1.3-4.7). The mean time from most recent episode of acute prostatitis to the diagnosis of prostate cancer was 12.2 years. After exclusion of men with acute prostatitis 2 years before the index date, the relationship was somewhat reduced (1.9; 0.9-3.8). Chronic bacterial prostatitis was more weakly associated with prostate cancer (1.6; 0.8-3.1), whereas chronic pelvic pain syndrome was not associated at all (0.9; 0.4-1.8). Conclusions: Infection in the form of acute or chronic bacterial prostatitis may be associated with prostate cancer. However, our data do not provide compelling evidence to support this. As a result of the limitations of current methods of assessing chronic prostatitis, biochemical or tissue markers of infection or inflammation of the prostate may help clarify their role in the pathogenesis of prostate cancer.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalEpidemiology
Volume15
Issue number1
DOIs
StatePublished - Jan 2004

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Prostatitis
Prostatic Neoplasms
Pelvic Pain
Chronic Pain
Medical Records
Prostate
Infection
Odds Ratio
Inflammation
Internship and Residency
Confidence Intervals

ASJC Scopus subject areas

  • Epidemiology

Cite this

Roberts, R. O., Bergstralh, E. J., Bass, S. E., Lieber, M. M., & Jacobsen, S. J. (2004). Prostatitis as a risk factor for prostate cancer. Epidemiology, 15(1), 93-99. https://doi.org/10.1097/01.ede.0000101022.38330.7c

Prostatitis as a risk factor for prostate cancer. / Roberts, Rosebud O; Bergstralh, Erik J.; Bass, Sarah E.; Lieber, Michael M.; Jacobsen, Steven J.

In: Epidemiology, Vol. 15, No. 1, 01.2004, p. 93-99.

Research output: Contribution to journalArticle

Roberts, RO, Bergstralh, EJ, Bass, SE, Lieber, MM & Jacobsen, SJ 2004, 'Prostatitis as a risk factor for prostate cancer', Epidemiology, vol. 15, no. 1, pp. 93-99. https://doi.org/10.1097/01.ede.0000101022.38330.7c
Roberts RO, Bergstralh EJ, Bass SE, Lieber MM, Jacobsen SJ. Prostatitis as a risk factor for prostate cancer. Epidemiology. 2004 Jan;15(1):93-99. https://doi.org/10.1097/01.ede.0000101022.38330.7c
Roberts, Rosebud O ; Bergstralh, Erik J. ; Bass, Sarah E. ; Lieber, Michael M. ; Jacobsen, Steven J. / Prostatitis as a risk factor for prostate cancer. In: Epidemiology. 2004 ; Vol. 15, No. 1. pp. 93-99.
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