Prostate cancer regulatory networks

Dario C. Altieri, Lucia R. Languino, Jane B. Lian, Janet L. Stein, Irwin Leav, Andre J. Van Wijnen, Zhong Jiang, Gary S. Stein

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Although the timing with which common epithelial malignancies arise and become established remains a matter of debate, it is clear that by the time they are detected these tumors harbor hundreds of deregulated, aberrantly expressed or mutated genes. This enormous complexity poses formidable challenges to identify gene pathways that are drivers of tumorigenesis, potentially suitable for therapeutic intervention. An alternative approach is to consider cancer pathways as interconnected networks, and search for potential nodal proteins capable of connecting multiple signaling networks of tumor maintenance. We have modeled this approach in advanced prostate cancer, a condition with current limited therapeutic options. We propose that the integration of three signaling networks, including chaperone-mediated mitochondrial homeostasis, integrin-dependent cell signaling, and Runx2-regulated gene expression in the metastatic bone microenvironment plays a critical role in prostate cancer maintenance, and offers novel options for molecular therapy.

Original languageEnglish (US)
Pages (from-to)845-852
Number of pages8
JournalJournal of cellular biochemistry
Issue number5
StatePublished - Aug 1 2009


  • Integrins
  • Prostate cancer
  • Regulatory networks
  • Runx
  • Signaling
  • Survivin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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