TY - JOUR
T1 - Prostate cancer in pilots
AU - Raslau, David
AU - Dabrh, Abd Moain Abu
AU - Summerfield, Douglas T.
AU - Wang, Zhen
AU - Steinkraus, Lawrence W.
AU - Murad, Mohammad Hassan
N1 - Publisher Copyright:
© by the Aerospace Medical Association, Alexandria, VA.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - BACKGROUND: Aviation exposes pilots to various occupationally related hazards, including ionizing radiation and chemical combustion. The possibility of increased prostate cancer incidence and mortality among pilots is a subject of debate. This systematic review and meta-analysis aims to summarize the supporting evidence and determine the magnitude of association. METHODS: All studies reporting prostate cancer incidence and mortality in pilots compared to the general population were included regardless of language or size. The comprehensive search included multiple databases and manual search. A random effect model was used to pool relative risks (RR) across studies. RESULTS: The final search yielded nine studies with good methodological quality. Four studies reported the incidence of prostate cancer while six reported on mortality. Pilots had a small but statistically significant increase in the risk of developing prostate cancer [RR 1.20; 95% confidence interval (CI), 1.08-1.33], but not in prostate cancer mortality (RR 1.20; 95% CI, 0.91-1.60). CONCLUSION: Pilots appear to have a very small increase in prostate cancer incidence, but not in mortality. The clinical significance of this finding is uncertain.
AB - BACKGROUND: Aviation exposes pilots to various occupationally related hazards, including ionizing radiation and chemical combustion. The possibility of increased prostate cancer incidence and mortality among pilots is a subject of debate. This systematic review and meta-analysis aims to summarize the supporting evidence and determine the magnitude of association. METHODS: All studies reporting prostate cancer incidence and mortality in pilots compared to the general population were included regardless of language or size. The comprehensive search included multiple databases and manual search. A random effect model was used to pool relative risks (RR) across studies. RESULTS: The final search yielded nine studies with good methodological quality. Four studies reported the incidence of prostate cancer while six reported on mortality. Pilots had a small but statistically significant increase in the risk of developing prostate cancer [RR 1.20; 95% confidence interval (CI), 1.08-1.33], but not in prostate cancer mortality (RR 1.20; 95% CI, 0.91-1.60). CONCLUSION: Pilots appear to have a very small increase in prostate cancer incidence, but not in mortality. The clinical significance of this finding is uncertain.
KW - Aviation
KW - Incidence
KW - Mortality
KW - Pilots
KW - Prostate cancer
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U2 - 10.3357/AMHP.4453.2016
DO - 10.3357/AMHP.4453.2016
M3 - Article
C2 - 27208680
AN - SCOPUS:84982873196
SN - 2375-6314
VL - 87
SP - 565
EP - 570
JO - Aerospace Medicine and Human Performance
JF - Aerospace Medicine and Human Performance
IS - 6
ER -