Prostate cancer immunology: Biology, therapeutics, and challenges

W. Scott Webster, Eric J. Small, Brian I. Rini, Eugene D. Kwon

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

A number of recently developed and promising approaches to antitumoral immunotherapy are being investigated as potential treatments for advanced prostate cancer. These approaches largely revolve around strategies to increase antigen-specific T-cell activation against prostate tumors as well as precise manipulations of critical co-regulatory receptors that help to maintain and prolong the activity of antigen-presenting cells and T cells that are capable of mediating tumor regression. Herein, we describe the experience with the most recent and promising approaches pertaining to prostate cancer immunotherapy. Additionally, we discuss the mechanistic basis for these approaches as well as current limitations that must still be addressed in order to propel immunotherapy into the forefront of prostate cancer treatment.

Original languageEnglish (US)
Pages (from-to)8262-8269
Number of pages8
JournalJournal of Clinical Oncology
Volume23
Issue number32
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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