Prostate cancer and genetic susceptibility

A genome scan incorporating disease aggressiveness

Janet L. Stanford, Shannon K. McDonnell, Danielle M. Friedrichsen, Erin E. Carlson, Suzanne Kolb, Kerry Deutsch, Marta Janer, Lee Hood, Elaine A. Ostrander, Daniel J Schaid

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

BACKGROUND. Prostate cancer is a heterogeneous disease, both genetically and phenotypically. Linkage studies attempting to map genes for hereditary prostate cancer (HPC) have proved challenging, and one potential problem contributing to this challenge is the variability in disease phenotypes. METHODS. We collected clinical data on 784 affected men with prostate cancer from 248 HPC families for whom a genomic screen was performed. Disease characteristics (i.e., Gleason score, stage, prostate-specific antigen (PSA)) were used to classify affected men into categories of clinically insignificant, moderate, or aggressive prostate cancer. To potentially enrich for a genetic etiology, we restricted linkage analyses to only men with aggressive disease, although we used genotype information from all family members; linkage analyses used both dominant and recessive models. In addition, subset analyses considered age at diagnosis, number of affected men per family and other stratifications to try to increase genetic homogeneity. RESULTS. Several regions of interest (heterogeneity LOD score, HLOD > 1.0) were identified in families (n = 123) with ≥2 affecteds with aggressive prostate cancer. "Suggestive" linkage was observed at chromosome 22q11.1 (Dominant model HLOD = 2.18) and the result was stronger (Dominant HLOD = 2.75) in families with evidence of male-to-male transmission. A second region at 22q12.3-q13.1 was also highlighted (Recessive model HLOD = 1.90) among men with aggressive disease, as was a region on chromosome 18. CONCLUSIONS. These analyses suggest that using clinically defined phenotypes may be a useful approach for simplifying the locus heterogeneity problems that confound the search for prostate cancer susceptibility genes.

Original languageEnglish (US)
Pages (from-to)317-325
Number of pages9
JournalProstate
Volume66
Issue number3
DOIs
StatePublished - Feb 15 2006

Fingerprint

Genetic Predisposition to Disease
Prostatic Neoplasms
Genome
Phenotype
Chromosomes, Human, Pair 18
Neoplasm Grading
Neoplasm Genes
Prostate-Specific Antigen
Chromosomes
Genotype
Genes
Familial Prostate cancer

Keywords

  • Aggressive prostate cancer
  • Genetic susceptibility
  • Gleason score
  • Hereditary prostate cancer
  • LOD score
  • Prostate-specific antigen

ASJC Scopus subject areas

  • Urology

Cite this

Stanford, J. L., McDonnell, S. K., Friedrichsen, D. M., Carlson, E. E., Kolb, S., Deutsch, K., ... Schaid, D. J. (2006). Prostate cancer and genetic susceptibility: A genome scan incorporating disease aggressiveness. Prostate, 66(3), 317-325. https://doi.org/10.1002/pros.20349

Prostate cancer and genetic susceptibility : A genome scan incorporating disease aggressiveness. / Stanford, Janet L.; McDonnell, Shannon K.; Friedrichsen, Danielle M.; Carlson, Erin E.; Kolb, Suzanne; Deutsch, Kerry; Janer, Marta; Hood, Lee; Ostrander, Elaine A.; Schaid, Daniel J.

In: Prostate, Vol. 66, No. 3, 15.02.2006, p. 317-325.

Research output: Contribution to journalArticle

Stanford, JL, McDonnell, SK, Friedrichsen, DM, Carlson, EE, Kolb, S, Deutsch, K, Janer, M, Hood, L, Ostrander, EA & Schaid, DJ 2006, 'Prostate cancer and genetic susceptibility: A genome scan incorporating disease aggressiveness', Prostate, vol. 66, no. 3, pp. 317-325. https://doi.org/10.1002/pros.20349
Stanford JL, McDonnell SK, Friedrichsen DM, Carlson EE, Kolb S, Deutsch K et al. Prostate cancer and genetic susceptibility: A genome scan incorporating disease aggressiveness. Prostate. 2006 Feb 15;66(3):317-325. https://doi.org/10.1002/pros.20349
Stanford, Janet L. ; McDonnell, Shannon K. ; Friedrichsen, Danielle M. ; Carlson, Erin E. ; Kolb, Suzanne ; Deutsch, Kerry ; Janer, Marta ; Hood, Lee ; Ostrander, Elaine A. ; Schaid, Daniel J. / Prostate cancer and genetic susceptibility : A genome scan incorporating disease aggressiveness. In: Prostate. 2006 ; Vol. 66, No. 3. pp. 317-325.
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N2 - BACKGROUND. Prostate cancer is a heterogeneous disease, both genetically and phenotypically. Linkage studies attempting to map genes for hereditary prostate cancer (HPC) have proved challenging, and one potential problem contributing to this challenge is the variability in disease phenotypes. METHODS. We collected clinical data on 784 affected men with prostate cancer from 248 HPC families for whom a genomic screen was performed. Disease characteristics (i.e., Gleason score, stage, prostate-specific antigen (PSA)) were used to classify affected men into categories of clinically insignificant, moderate, or aggressive prostate cancer. To potentially enrich for a genetic etiology, we restricted linkage analyses to only men with aggressive disease, although we used genotype information from all family members; linkage analyses used both dominant and recessive models. In addition, subset analyses considered age at diagnosis, number of affected men per family and other stratifications to try to increase genetic homogeneity. RESULTS. Several regions of interest (heterogeneity LOD score, HLOD > 1.0) were identified in families (n = 123) with ≥2 affecteds with aggressive prostate cancer. "Suggestive" linkage was observed at chromosome 22q11.1 (Dominant model HLOD = 2.18) and the result was stronger (Dominant HLOD = 2.75) in families with evidence of male-to-male transmission. A second region at 22q12.3-q13.1 was also highlighted (Recessive model HLOD = 1.90) among men with aggressive disease, as was a region on chromosome 18. CONCLUSIONS. These analyses suggest that using clinically defined phenotypes may be a useful approach for simplifying the locus heterogeneity problems that confound the search for prostate cancer susceptibility genes.

AB - BACKGROUND. Prostate cancer is a heterogeneous disease, both genetically and phenotypically. Linkage studies attempting to map genes for hereditary prostate cancer (HPC) have proved challenging, and one potential problem contributing to this challenge is the variability in disease phenotypes. METHODS. We collected clinical data on 784 affected men with prostate cancer from 248 HPC families for whom a genomic screen was performed. Disease characteristics (i.e., Gleason score, stage, prostate-specific antigen (PSA)) were used to classify affected men into categories of clinically insignificant, moderate, or aggressive prostate cancer. To potentially enrich for a genetic etiology, we restricted linkage analyses to only men with aggressive disease, although we used genotype information from all family members; linkage analyses used both dominant and recessive models. In addition, subset analyses considered age at diagnosis, number of affected men per family and other stratifications to try to increase genetic homogeneity. RESULTS. Several regions of interest (heterogeneity LOD score, HLOD > 1.0) were identified in families (n = 123) with ≥2 affecteds with aggressive prostate cancer. "Suggestive" linkage was observed at chromosome 22q11.1 (Dominant model HLOD = 2.18) and the result was stronger (Dominant HLOD = 2.75) in families with evidence of male-to-male transmission. A second region at 22q12.3-q13.1 was also highlighted (Recessive model HLOD = 1.90) among men with aggressive disease, as was a region on chromosome 18. CONCLUSIONS. These analyses suggest that using clinically defined phenotypes may be a useful approach for simplifying the locus heterogeneity problems that confound the search for prostate cancer susceptibility genes.

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