Prostacyclin and noradrenaline in peripheral nerve of chronic experimental diabetes in rats

Kim K. Ward; Phillip A. Low; James D. Schmelzer; Douglas W. Zochodne

doi:10.1093/brain/112.1.197

Prostacyclin and noradrenaline in peripheral nerve of chronic experimental diabetes in rats

Kim K. Ward, Phillip A. Low, James D. Schmelzer, Douglas W. Zochodne

Neurology

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Abstract

Noradrenaline levels in the superior cervical ganglion and sciatic nerve were significantly reduced in chronic streptozotocin-induced diabetes in rats. Sciatic nerve sheath in vitro biosynthesis of 6-keto prostaglandin F₁₂ (6KPGF_1a; the stable metabolite of prostacyclin) was significantly reduced but not in acute experimental diabetes Nerves with reduced 6KPGF_1a had an excessive response to arachidonic acid stimulation We suggest that the reduced endogenous biosynthesis of prostacyclin is due to reduced substrate availability, possibly due to the reduced noradrenaline The implications of these findings on the pathogenesis of diabetic neuropathy are discussed. Neuropathy was found to involve all fibre populations studied (motor, sensory and sympathetic) and progressed with duration of diabetes.

Original language	English (US)
Pages (from-to)	197-208
Number of pages	12
Journal	Brain
Volume	112
Issue number	1
DOIs	https://doi.org/10.1093/brain/112.1.197
State	Published - Feb 1989

ASJC Scopus subject areas

Clinical Neurology

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title = "Prostacyclin and noradrenaline in peripheral nerve of chronic experimental diabetes in rats",

abstract = "Noradrenaline levels in the superior cervical ganglion and sciatic nerve were significantly reduced in chronic streptozotocin-induced diabetes in rats. Sciatic nerve sheath in vitro biosynthesis of 6-keto prostaglandin F12 (6KPGF1a; the stable metabolite of prostacyclin) was significantly reduced but not in acute experimental diabetes Nerves with reduced 6KPGF1a had an excessive response to arachidonic acid stimulation We suggest that the reduced endogenous biosynthesis of prostacyclin is due to reduced substrate availability, possibly due to the reduced noradrenaline The implications of these findings on the pathogenesis of diabetic neuropathy are discussed. Neuropathy was found to involve all fibre populations studied (motor, sensory and sympathetic) and progressed with duration of diabetes.",

author = "Ward, {Kim K.} and Low, {Phillip A.} and Schmelzer, {James D.} and Zochodne, {Douglas W.}",

note = "Funding Information: This study was supported in part by grants from NINCDS (RO1 NS2 2352, NS14302), MDA, Mogg and Mayo Funds. Dr Zochodne is a fellow of the Medical Research Council of Canada. Dr Low is a recipient of a Jacob Javits neuroscience investigator award.",

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doi = "10.1093/brain/112.1.197",

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T1 - Prostacyclin and noradrenaline in peripheral nerve of chronic experimental diabetes in rats

AU - Ward, Kim K.

AU - Low, Phillip A.

AU - Schmelzer, James D.

AU - Zochodne, Douglas W.

N1 - Funding Information: This study was supported in part by grants from NINCDS (RO1 NS2 2352, NS14302), MDA, Mogg and Mayo Funds. Dr Zochodne is a fellow of the Medical Research Council of Canada. Dr Low is a recipient of a Jacob Javits neuroscience investigator award.

PY - 1989/2

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N2 - Noradrenaline levels in the superior cervical ganglion and sciatic nerve were significantly reduced in chronic streptozotocin-induced diabetes in rats. Sciatic nerve sheath in vitro biosynthesis of 6-keto prostaglandin F12 (6KPGF1a; the stable metabolite of prostacyclin) was significantly reduced but not in acute experimental diabetes Nerves with reduced 6KPGF1a had an excessive response to arachidonic acid stimulation We suggest that the reduced endogenous biosynthesis of prostacyclin is due to reduced substrate availability, possibly due to the reduced noradrenaline The implications of these findings on the pathogenesis of diabetic neuropathy are discussed. Neuropathy was found to involve all fibre populations studied (motor, sensory and sympathetic) and progressed with duration of diabetes.

AB - Noradrenaline levels in the superior cervical ganglion and sciatic nerve were significantly reduced in chronic streptozotocin-induced diabetes in rats. Sciatic nerve sheath in vitro biosynthesis of 6-keto prostaglandin F12 (6KPGF1a; the stable metabolite of prostacyclin) was significantly reduced but not in acute experimental diabetes Nerves with reduced 6KPGF1a had an excessive response to arachidonic acid stimulation We suggest that the reduced endogenous biosynthesis of prostacyclin is due to reduced substrate availability, possibly due to the reduced noradrenaline The implications of these findings on the pathogenesis of diabetic neuropathy are discussed. Neuropathy was found to involve all fibre populations studied (motor, sensory and sympathetic) and progressed with duration of diabetes.

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Prostacyclin and noradrenaline in peripheral nerve of chronic experimental diabetes in rats

Abstract

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