Prostacyclin and noradrenaline in peripheral nerve of chronic experimental diabetes in rats

Kim K. Ward, Phillip A. Low, James D. Schmelzer, Douglas W. Zochodne

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

Noradrenaline levels in the superior cervical ganglion and sciatic nerve were significantly reduced in chronic streptozotocin-induced diabetes in rats. Sciatic nerve sheath in vitro biosynthesis of 6-keto prostaglandin F12 (6KPGF1a; the stable metabolite of prostacyclin) was significantly reduced but not in acute experimental diabetes Nerves with reduced 6KPGF1a had an excessive response to arachidonic acid stimulation We suggest that the reduced endogenous biosynthesis of prostacyclin is due to reduced substrate availability, possibly due to the reduced noradrenaline The implications of these findings on the pathogenesis of diabetic neuropathy are discussed. Neuropathy was found to involve all fibre populations studied (motor, sensory and sympathetic) and progressed with duration of diabetes.

Original languageEnglish (US)
Pages (from-to)197-208
Number of pages12
JournalBrain
Volume112
Issue number1
DOIs
StatePublished - Feb 1 1989

ASJC Scopus subject areas

  • Clinical Neurology

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