Prospects and opportunities for microsystems and microfluidic devices in the field of otorhinolaryngology

Se Hwan Hwang, Alan M. Gonzalez-Suarez, Gulnaz Stybayeva, Alexander Revzin

Research output: Contribution to journalReview articlepeer-review

Abstract

Microfluidic systems can be used to control picoliter to microliter volumes in ways not possible with other methods of fluid handling. In recent years, the field of microfluidics has grown rapidly, with microfluidic devices offering possibilities to impact biology and medicine. Microfluidic devices populated with human cells have the potential to mimic the physiological functions of tissues and organs in a three-dimensional microenvironment and enable the study of mechanisms of human diseases, drug discovery and the practice of personalized medicine. In the field of otorhinolaryngology, various types of microfluidic systems have already been introduced to study organ physiology, diagnose diseases, and evaluate therapeutic efficacy. Therefore, microfluidic technologies can be implemented at all levels of otorhinolaryngology. This review is intended to promote understanding of microfluidic properties and introduce the recent literature on application of microfluidic-related devices in the field of otorhinolaryngology.

Original languageEnglish (US)
Pages (from-to)29-42
Number of pages14
JournalClinical and Experimental Otorhinolaryngology
Volume14
Issue number1
DOIs
StatePublished - Feb 2021

Keywords

  • In Vitro Diagnostics
  • Microfluidics
  • Organ-on-a-Chip
  • Organoids
  • Otolaryngology

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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