PERSPEKTIVEN DER GENTHERAPIE BEI RHEUMATISCHEN UND DEGENERATIVEN ERKRANKUNGEN DER WIRBELSAULE UND DER GELENKE

Translated title of the contribution: Prospectives of gentherapy in orthopaedic diseases of the spine and the joints

C. H. Evans, P. Wehling, J. Reinecke

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Rheumatoid degenerative conditions of the spine and other joints are most common in elderly patients. Data by the 'National Center for Health Statistics' state that approximatly 500 in 1000 persons above 65 are affected. Numbers for Germany should be in the same range. Although a lot of research has been dedicated to these conditions many of the actual causes remain unclear. There is consensus about the involvement of Interleukin-1 in the development of rheumatoid arthritis RA. Recent results point towards a more refined understanding and a gene therapy approach utilizing synovial cells. The synovium will in this strategy be the locus of drug (eg hormone) synthesis antagonizing the rheumatoid disease. We believe that this new approach will have a major impact on the treatment of RA.

Translated title of the contributionProspectives of gentherapy in orthopaedic diseases of the spine and the joints
Original languageGerman
Pages (from-to)449-452
Number of pages4
JournalZeitschrift fur Orthopadie und Ihre Grenzgebiete
Volume132
Issue number6
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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