PERSPEKTIVEN DER GENTHERAPIE BEI RHEUMATISCHEN UND DEGENERATIVEN ERKRANKUNGEN DER WIRBELSAULE UND DER GELENKE

C. H. Evans; P. Wehling; J. Reinecke

doi:10.1055/s-2008-1039467

PERSPEKTIVEN DER GENTHERAPIE BEI RHEUMATISCHEN UND DEGENERATIVEN ERKRANKUNGEN DER WIRBELSAULE UND DER GELENKE

Translated title of the contribution: Prospectives of gentherapy in orthopaedic diseases of the spine and the joints

C. H. Evans, P. Wehling, J. Reinecke

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Rheumatoid degenerative conditions of the spine and other joints are most common in elderly patients. Data by the 'National Center for Health Statistics' state that approximatly 500 in 1000 persons above 65 are affected. Numbers for Germany should be in the same range. Although a lot of research has been dedicated to these conditions many of the actual causes remain unclear. There is consensus about the involvement of Interleukin-1 in the development of rheumatoid arthritis RA. Recent results point towards a more refined understanding and a gene therapy approach utilizing synovial cells. The synovium will in this strategy be the locus of drug (eg hormone) synthesis antagonizing the rheumatoid disease. We believe that this new approach will have a major impact on the treatment of RA.

Translated title of the contribution	Prospectives of gentherapy in orthopaedic diseases of the spine and the joints
Original language	German
Pages (from-to)	449-452
Number of pages	4
Journal	Zeitschrift fur Orthopadie und Ihre Grenzgebiete
Volume	132
Issue number	6
DOIs	https://doi.org/10.1055/s-2008-1039467
State	Published - 1994

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine

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abstract = "Rheumatoid degenerative conditions of the spine and other joints are most common in elderly patients. Data by the 'National Center for Health Statistics' state that approximatly 500 in 1000 persons above 65 are affected. Numbers for Germany should be in the same range. Although a lot of research has been dedicated to these conditions many of the actual causes remain unclear. There is consensus about the involvement of Interleukin-1 in the development of rheumatoid arthritis RA. Recent results point towards a more refined understanding and a gene therapy approach utilizing synovial cells. The synovium will in this strategy be the locus of drug (eg hormone) synthesis antagonizing the rheumatoid disease. We believe that this new approach will have a major impact on the treatment of RA.",

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PERSPEKTIVEN DER GENTHERAPIE BEI RHEUMATISCHEN UND DEGENERATIVEN ERKRANKUNGEN DER WIRBELSAULE UND DER GELENKE

Abstract

ASJC Scopus subject areas

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