Prospective, randomized trial of higher goal hemoglobin after subarachnoid hemorrhage

Andrew M. Naidech, Ali Shaibani, Rajeev K. Garg, Isis M. Duran, Storm M. Liebling, Sarice L. Bassin, Bernard Bendok, Richard A. Bernstein, H. Hunt Batjer, Mark J. Alberts

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background: and Purpose: In patients with subarachnoid hemorrhage (SAH), higher hemoglobin (HGB) has been associated with better outcomes, but packed red blood cell (PRBC) transfusions with worse outcomes. We performed a prospective pilot trial of goal HGB after SAH. Methods: Forty-four patients with SAH and high risk for vasospasm were randomized to goal HGB concentration of at least 10 or 11.5 g/dl. We obtained blinded clinical outcomes at 14 days (NIH Stroke Scale and modified Rankin Scale, mRS), 28 days (mRS), and 3 months (mRS), and blinded interpretation of brain MRI for cerebral infarction at 14 days. This trial is registered at www.stroketrials.org . Results: Forty-four patients were randomized. Patients with goal HGB 11.5 g/dl received more PRBC units per transfusion [1 (1-2) vs. 1 (1-1), P < 0.001] and more total PRBC units [3 (2-4) vs. 2 (1-3), P = 0.045]. Prospectively defined safety endpoints were not different between groups. HGB concentration was different between study groups from day 4 onwards. The number of cerebral infarctions on MRI (6 of 20 vs. 9 of 22), NIH Stroke Scale scores at 14 days [1 (0-9.75) vs. 2 (0-16)], and rates of independence on the mRS at 14 days (65% vs. 44%) and 28 days (80% vs. 67%) were similar, but favored higher goal HGB (P > 0.1 for all). Conclusions: Higher goal hemoglobin in patients with SAH seems to be safe and feasible. A phase III trial of goal HGB after SAH is warranted.

Original languageEnglish (US)
Pages (from-to)313-320
Number of pages8
JournalNeurocritical Care
Volume13
Issue number3
DOIs
StatePublished - Dec 2010
Externally publishedYes

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Subarachnoid Hemorrhage
Hemoglobins
Erythrocyte Transfusion
Cerebral Infarction
Erythrocytes
Stroke
Brain

Keywords

  • Anemia
  • Outcomes
  • Subarachnoid hemorrhage
  • Transfusion

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine

Cite this

Naidech, A. M., Shaibani, A., Garg, R. K., Duran, I. M., Liebling, S. M., Bassin, S. L., ... Alberts, M. J. (2010). Prospective, randomized trial of higher goal hemoglobin after subarachnoid hemorrhage. Neurocritical Care, 13(3), 313-320. https://doi.org/10.1007/s12028-010-9424-4

Prospective, randomized trial of higher goal hemoglobin after subarachnoid hemorrhage. / Naidech, Andrew M.; Shaibani, Ali; Garg, Rajeev K.; Duran, Isis M.; Liebling, Storm M.; Bassin, Sarice L.; Bendok, Bernard; Bernstein, Richard A.; Batjer, H. Hunt; Alberts, Mark J.

In: Neurocritical Care, Vol. 13, No. 3, 12.2010, p. 313-320.

Research output: Contribution to journalArticle

Naidech, AM, Shaibani, A, Garg, RK, Duran, IM, Liebling, SM, Bassin, SL, Bendok, B, Bernstein, RA, Batjer, HH & Alberts, MJ 2010, 'Prospective, randomized trial of higher goal hemoglobin after subarachnoid hemorrhage', Neurocritical Care, vol. 13, no. 3, pp. 313-320. https://doi.org/10.1007/s12028-010-9424-4
Naidech AM, Shaibani A, Garg RK, Duran IM, Liebling SM, Bassin SL et al. Prospective, randomized trial of higher goal hemoglobin after subarachnoid hemorrhage. Neurocritical Care. 2010 Dec;13(3):313-320. https://doi.org/10.1007/s12028-010-9424-4
Naidech, Andrew M. ; Shaibani, Ali ; Garg, Rajeev K. ; Duran, Isis M. ; Liebling, Storm M. ; Bassin, Sarice L. ; Bendok, Bernard ; Bernstein, Richard A. ; Batjer, H. Hunt ; Alberts, Mark J. / Prospective, randomized trial of higher goal hemoglobin after subarachnoid hemorrhage. In: Neurocritical Care. 2010 ; Vol. 13, No. 3. pp. 313-320.
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abstract = "Background: and Purpose: In patients with subarachnoid hemorrhage (SAH), higher hemoglobin (HGB) has been associated with better outcomes, but packed red blood cell (PRBC) transfusions with worse outcomes. We performed a prospective pilot trial of goal HGB after SAH. Methods: Forty-four patients with SAH and high risk for vasospasm were randomized to goal HGB concentration of at least 10 or 11.5 g/dl. We obtained blinded clinical outcomes at 14 days (NIH Stroke Scale and modified Rankin Scale, mRS), 28 days (mRS), and 3 months (mRS), and blinded interpretation of brain MRI for cerebral infarction at 14 days. This trial is registered at www.stroketrials.org . Results: Forty-four patients were randomized. Patients with goal HGB 11.5 g/dl received more PRBC units per transfusion [1 (1-2) vs. 1 (1-1), P < 0.001] and more total PRBC units [3 (2-4) vs. 2 (1-3), P = 0.045]. Prospectively defined safety endpoints were not different between groups. HGB concentration was different between study groups from day 4 onwards. The number of cerebral infarctions on MRI (6 of 20 vs. 9 of 22), NIH Stroke Scale scores at 14 days [1 (0-9.75) vs. 2 (0-16)], and rates of independence on the mRS at 14 days (65{\%} vs. 44{\%}) and 28 days (80{\%} vs. 67{\%}) were similar, but favored higher goal HGB (P > 0.1 for all). Conclusions: Higher goal hemoglobin in patients with SAH seems to be safe and feasible. A phase III trial of goal HGB after SAH is warranted.",
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AU - Shaibani, Ali

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AU - Liebling, Storm M.

AU - Bassin, Sarice L.

AU - Bendok, Bernard

AU - Bernstein, Richard A.

AU - Batjer, H. Hunt

AU - Alberts, Mark J.

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KW - Anemia

KW - Outcomes

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