Prospective evaluation of in vivo proton MR spectroscopy in differentiation of similar appearing intracranial cystic lesions

A. Shukla-Dave, R. K. Gupta, R. Roy, N. Husain, L. Paul, Sudhakar K Venkatesh, M. R. Rashid, D. K. Chhabra, M. Husain

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Proton MR spectroscopy (PMRS) has been found to be useful in differentiating various cystic intracranial lesions. The purpose of the present study was to prospectively evaluate the spectral pattern of various cystic lesions of brain with similar imaging appearances and to determine the accuracy of this technique in the differential diagnosis of these lesions. Fifty-one patients with intracranial cystic lesions (21 abscesses, 20 gliomas, 3 hydatid cysts, 3 arachnoid cysts, 1 case each of glioependymal cyst, xanthogranuloma, infarction and acoustic neuroma) were evaluated with conventional MR imaging and in vivo PMRS. Ex vivo PMRS of the cystic contents aspirated at surgery in 31 cases was also done to confirm the in-vivo results. Preoperative diagnosis of the lesions was based on the results of in vivo PMRS. In vivo PMRS accurately predicted the pathology in 92% of the cases. We conclude that in-vivo PMRS complements imaging in better characterization of cystic intracranial mass lesions.

Original languageEnglish (US)
Pages (from-to)103-110
Number of pages8
JournalMagnetic Resonance Imaging
Volume19
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

lesions
Protons
Magnetic Resonance Spectroscopy
Spectroscopy
cysts
protons
evaluation
spectroscopy
Imaging techniques
infarction
Arachnoid Cysts
Acoustic Neuroma
Echinococcosis
pathology
Pathology
surgery
Glioma
complement
Abscess
Surgery

Keywords

  • Brain
  • Cystic lesions
  • MR spectroscopy
  • MRI

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Prospective evaluation of in vivo proton MR spectroscopy in differentiation of similar appearing intracranial cystic lesions. / Shukla-Dave, A.; Gupta, R. K.; Roy, R.; Husain, N.; Paul, L.; Venkatesh, Sudhakar K; Rashid, M. R.; Chhabra, D. K.; Husain, M.

In: Magnetic Resonance Imaging, Vol. 19, No. 1, 2001, p. 103-110.

Research output: Contribution to journalArticle

Shukla-Dave, A. ; Gupta, R. K. ; Roy, R. ; Husain, N. ; Paul, L. ; Venkatesh, Sudhakar K ; Rashid, M. R. ; Chhabra, D. K. ; Husain, M. / Prospective evaluation of in vivo proton MR spectroscopy in differentiation of similar appearing intracranial cystic lesions. In: Magnetic Resonance Imaging. 2001 ; Vol. 19, No. 1. pp. 103-110.
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abstract = "Proton MR spectroscopy (PMRS) has been found to be useful in differentiating various cystic intracranial lesions. The purpose of the present study was to prospectively evaluate the spectral pattern of various cystic lesions of brain with similar imaging appearances and to determine the accuracy of this technique in the differential diagnosis of these lesions. Fifty-one patients with intracranial cystic lesions (21 abscesses, 20 gliomas, 3 hydatid cysts, 3 arachnoid cysts, 1 case each of glioependymal cyst, xanthogranuloma, infarction and acoustic neuroma) were evaluated with conventional MR imaging and in vivo PMRS. Ex vivo PMRS of the cystic contents aspirated at surgery in 31 cases was also done to confirm the in-vivo results. Preoperative diagnosis of the lesions was based on the results of in vivo PMRS. In vivo PMRS accurately predicted the pathology in 92{\%} of the cases. We conclude that in-vivo PMRS complements imaging in better characterization of cystic intracranial mass lesions.",
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