Proposed standard nomenclature for new tumor necrosis factor members involved in the regulation of bone resorption

The American Society For Bone And Mineral Research President'S Committee On Nomenclature

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Recently, three new family members of the tumor necrosis factor (TNF) ligand and receptor signaling system that play a critical role in the regulation of bone resorption have been identified and cloned. These also have been shown to play an important role in regulating the immune system. A proliferation of synonyms for these molecules has led to miscommunication and redundancy. To resolve this, the President of the American Society for Bone and Mineral Research (ASBMR) appointed a special committee to recommend a standard nomenclature. After considerable deliberation and after vetting by workers in the field, the Committee recommends the names of receptor activator of NF-κB (RANKL) for the membrane receptor, RANK ligand (RANK) for the ligand, and osteoprotegerin (OPG) for the decoy receptor.

Original languageEnglish (US)
Pages (from-to)761-764
Number of pages4
JournalBone
Volume27
Issue number6
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

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