Proposed response assessment and endpoints for meningioma clinical trials: Report from the Response Assessment in Neuro-Oncology Working Group

Raymond Y. Huang; Wenya Linda Bi; Michael Weller; Thomas Kaley; Jaishri Blakeley; Ian Dunn; Evanthia Galanis; Matthias Preusser; Michael Mcdermott; Leland Rogers; Jeffrey Raizer; David Schiff; Riccardo Soffietti; Jörg Christian Tonn; Michael Vogelbaum; Damien Weber; David A. Reardon; Patrick Y. Wen

doi:10.1093/neuonc/noy137

Proposed response assessment and endpoints for meningioma clinical trials: Report from the Response Assessment in Neuro-Oncology Working Group

Raymond Y. Huang, Wenya Linda Bi, Michael Weller, Thomas Kaley, Jaishri Blakeley, Ian Dunn, Evanthia Galanis, Matthias Preusser, Michael Mcdermott, Leland Rogers, Jeffrey Raizer, David Schiff, Riccardo Soffietti, Jörg Christian Tonn, Michael Vogelbaum, Damien Weber, David A. Reardon, Patrick Y. Wen

Medical Oncology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

No standard criteria exist for assessing response and progression in clinical trials involving patients with meningioma, and there is no consensus on the optimal endpoints for trials currently under way. As a result, there is substantial variation in the design and response criteria of meningioma trials, making comparison between trials difficult. In addition, future trials should be designed with accepted standardized endpoints. The Response Assessment in Neuro-Oncology Meningioma Working Group is an international effort to develop standardized radiologic criteria for treatment response for meningioma clinical trials. In this proposal, we present the recommendations for response criteria and endpoints for clinical trials involving patients with meningiomas.

Original language	English (US)
Pages (from-to)	26-36
Number of pages	11
Journal	Neuro-oncology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1093/neuonc/noy137
State	Published - Jan 1 2019

Keywords

MRI
RANO
endpoint
meningioma
response

ASJC Scopus subject areas

Oncology
Clinical Neurology
Cancer Research

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Huang, R. Y., Bi, W. L., Weller, M., Kaley, T., Blakeley, J., Dunn, I., Galanis, E., Preusser, M., Mcdermott, M., Rogers, L., Raizer, J., Schiff, D., Soffietti, R., Tonn, J. C., Vogelbaum, M., Weber, D., Reardon, D. A., & Wen, P. Y. (2019). Proposed response assessment and endpoints for meningioma clinical trials: Report from the Response Assessment in Neuro-Oncology Working Group. Neuro-oncology, 21(1), 26-36. https://doi.org/10.1093/neuonc/noy137

Huang, RY, Bi, WL, Weller, M, Kaley, T, Blakeley, J, Dunn, I, Galanis, E, Preusser, M, Mcdermott, M, Rogers, L, Raizer, J, Schiff, D, Soffietti, R, Tonn, JC, Vogelbaum, M, Weber, D, Reardon, DA & Wen, PY 2019, 'Proposed response assessment and endpoints for meningioma clinical trials: Report from the Response Assessment in Neuro-Oncology Working Group', Neuro-oncology, vol. 21, no. 1, pp. 26-36. https://doi.org/10.1093/neuonc/noy137

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abstract = "No standard criteria exist for assessing response and progression in clinical trials involving patients with meningioma, and there is no consensus on the optimal endpoints for trials currently under way. As a result, there is substantial variation in the design and response criteria of meningioma trials, making comparison between trials difficult. In addition, future trials should be designed with accepted standardized endpoints. The Response Assessment in Neuro-Oncology Meningioma Working Group is an international effort to develop standardized radiologic criteria for treatment response for meningioma clinical trials. In this proposal, we present the recommendations for response criteria and endpoints for clinical trials involving patients with meningiomas.",

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author = "Huang, {Raymond Y.} and Bi, {Wenya Linda} and Michael Weller and Thomas Kaley and Jaishri Blakeley and Ian Dunn and Evanthia Galanis and Matthias Preusser and Michael Mcdermott and Leland Rogers and Jeffrey Raizer and David Schiff and Riccardo Soffietti and Tonn, {J{\"o}rg Christian} and Michael Vogelbaum and Damien Weber and Reardon, {David A.} and Wen, {Patrick Y.}",

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doi = "10.1093/neuonc/noy137",

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AU - Kaley, Thomas

AU - Blakeley, Jaishri

AU - Dunn, Ian

AU - Galanis, Evanthia

AU - Preusser, Matthias

AU - Mcdermott, Michael

AU - Rogers, Leland

AU - Raizer, Jeffrey

AU - Schiff, David

AU - Soffietti, Riccardo

AU - Tonn, Jörg Christian

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AU - Weber, Damien

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AU - Wen, Patrick Y.

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Proposed response assessment and endpoints for meningioma clinical trials: Report from the Response Assessment in Neuro-Oncology Working Group

Abstract

Keywords

ASJC Scopus subject areas

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