Proposed prognostic scoring system evaluating risk factors for biochemical recurrence of prostate cancer after salvage radiation therapy

Richard J. Lee, Katherine S. Tzou, Michael G. Heckman, Corey J. Hobbs, Bhupendra Rawal, Nancy N. Diehl, Jennifer L. Peterson, Nitesh N. Paryani, Stephen J. Ko, Larry C. Daugherty, Laura A. Vallow, William Wong, Steven Schild, Thomas M. Pisansky, Steven J. Buskirk

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objective: To update a previously proposed prognostic scoring system that predicts risk of biochemical recurrence (BCR) after salvage radiation therapy (SRT) for recurrent prostate cancer when using additional patients and a PSA value of 0.2 ng/mL and rising as the definition of BCR. Patients and Methods: We included 577 patients who received SRT for a rising PSA after radical prostatectomy in this retrospective cohort study. Clinical, pathological, and SRT characteristics were evaluated for association with BCR using relative risks (RRs) from multivariable Cox regression models. Results: With a median follow-up of 5.5 years after SRT, 354 patients (61%) experienced BCR. At 5 years after SRT, 40% of patients were free of BCR. Independent associations with BCR were identified for the PSA level before SRT (RR [doubling]: 1.25, P <0.001), pathological tumour stage (RR [T3a vs T2] 1.21, P = 0.19; RR [T3b/T4 vs T2] 2.09, P <0.001; overall P <0.001), Gleason score (RR [7 vs

Original languageEnglish (US)
Pages (from-to)236-242
Number of pages7
JournalBJU International
Volume118
Issue number2
DOIs
StatePublished - Aug 1 2016

Keywords

  • biochemical recurrence
  • prognostic factor
  • prostate cancer
  • salvage radiation therapy

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Proposed prognostic scoring system evaluating risk factors for biochemical recurrence of prostate cancer after salvage radiation therapy'. Together they form a unique fingerprint.

  • Cite this

    Lee, R. J., Tzou, K. S., Heckman, M. G., Hobbs, C. J., Rawal, B., Diehl, N. N., Peterson, J. L., Paryani, N. N., Ko, S. J., Daugherty, L. C., Vallow, L. A., Wong, W., Schild, S., Pisansky, T. M., & Buskirk, S. J. (2016). Proposed prognostic scoring system evaluating risk factors for biochemical recurrence of prostate cancer after salvage radiation therapy. BJU International, 118(2), 236-242. https://doi.org/10.1111/bju.13229