Abstract
Antibiotic-loaded bone cement (ABLC) is an effective delivery method of local antibiotics. ABLC for treatment should be high dose (>3.6 g per 40 g cement) for beads or spacers and 1 to 2 g antibiotic per 40 g cement for prosthesis fixation. Multiple antibiotics are required for treatment, with antibiotics being individualized according to culture susceptibilities. This approach requires hand mixing because there are no commercial high-dose products. ABLC should be low dose (≤1 g per 40 g cement) for prophylaxis purposes. Concerns with toxicity and cement mechanical properties are inconsequential with low-dose ABLC. Available clinical evidence supports low-dose ABLC for prophylaxis in revisions and high-risk primary joints, but concerns of emerging drug-resistant organisms probably outweigh routine use of low-dose ABLC in all uncomplicated primary arthroplasties.
Original language | English (US) |
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Pages (from-to) | 73-77 |
Number of pages | 5 |
Journal | Journal of Arthroplasty |
Volume | 19 |
Issue number | 4 SUPPL. 1 |
DOIs | |
State | Published - Jun 2004 |
Keywords
- Antibiotic prophylaxis
- Antibiotic-loaded bone cement
- Drug-resistant organisms
- Primary arthroplasty
ASJC Scopus subject areas
- Orthopedics and Sports Medicine