Prophylactic oophorectomy in colorectal carcinoma: Preliminary results of a randomized, prospective trial

Tonia M. Young-Fadok, Bruce G. Wolff, Santhat Nivatvongs, Philip P. Metzger, Duane M. Ilstrup

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Controversy exists regarding the role of prophylactic oophorectomy during resection for primary colorectal cancer. PURPOSE. A prospective, randomized trial was initiated to evaluate the influence of oophorectomy on recurrence and survival in patients with Dukes Stages B and C colorectal cancer. METHOD: Between November 1986 and March 1997, 155 patients were randomized to oophorectomy or no oophorectomy at laparotomy for resection of colorectal cancer. RESULTS: No incidence of gross or microscopic metastatic disease to the ovary was found among 77 patients randomized to oophorectomy, in contrast to previous reports. Preliminary crude survival curves suggested a survival bench for oophorectomy between two and three years from surgery, but Kaplan-Meier survival analysis indicated that this was not statistically significant and the benefit does not appear to persist at five years. Kaplan- Meier curves of recurrence-free survival, however, suggest a more substantial separation of the curves, with 80 percent vs. 65 percent: five-year disease- free survival for oophorectomy vs. nonoophorectomy, but further patient accrual is necessary to provide sufficient statistical power. CONCLUSIONS: Occult colorectal carcinoma metastatic to the ovaries has not been documented to this series of putative Dukes Stages B and C tumors. The possibility of a recurrence free survival advantage emphasizes the need to continue this preliminary work.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalDiseases of the Colon and Rectum
Volume41
Issue number3
DOIs
StatePublished - Mar 1998

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Ovariectomy
Colorectal Neoplasms
Survival
Recurrence
Ovary
Kaplan-Meier Estimate
Survival Analysis
Laparotomy
Disease-Free Survival
Incidence
Neoplasms

Keywords

  • Colon cancer
  • Metastases
  • Oophorectomy
  • Rectal cancer
  • Survival

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Prophylactic oophorectomy in colorectal carcinoma : Preliminary results of a randomized, prospective trial. / Young-Fadok, Tonia M.; Wolff, Bruce G.; Nivatvongs, Santhat; Metzger, Philip P.; Ilstrup, Duane M.

In: Diseases of the Colon and Rectum, Vol. 41, No. 3, 03.1998, p. 277-283.

Research output: Contribution to journalArticle

Young-Fadok, Tonia M. ; Wolff, Bruce G. ; Nivatvongs, Santhat ; Metzger, Philip P. ; Ilstrup, Duane M. / Prophylactic oophorectomy in colorectal carcinoma : Preliminary results of a randomized, prospective trial. In: Diseases of the Colon and Rectum. 1998 ; Vol. 41, No. 3. pp. 277-283.
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