Properties of the antigen specific suppressive T cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T cell factor in the H-2 histocompatibility complex

T. Tada, M. Taniguchi, C. S. David

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Abstract

The locus of the gene that codes for the antigen specific suppressive T cell factor was determined to be in a new subregion 'I J' which locates between I B and I C subregions in the H 2 histocompatibility complex. This was shown by 2 different lines of evidence: the absorbing capacity for the suppressive T cell factor of several alloantisera against restricted I subregions did not correlate with their specificity for previously known Ia molecules which are coded for by genes in I A and I C subregions, but was associated with the specificity for the products of genes putatively present between I B and I C subregions. By the occurrence of special recombinant strains, i.e. B10.A(5R), B10.A(3R), B1O.S(9R), and B10.HTT, which differ with respect to the I J subregion, the authors were able to produce alloantisera which distinguish I J subregion gene products. The absorption studies using these special alloantisera directed to I J subregion clearly indicated that the suppressive T cell factor is a product of I J subregion gene(s), and that the molecule is distinct from known Ia molecules expressed on splenic B cells. Taking advantage of the fact that there is a strict histocompatibility requirement for the effective suppression between the donor and recipient strains of the suppressive T cell factor, the authors were able to determine the required identities of the genes in the H 2 complex existing among those present between I B and I C. Again, utilizing the T cell factors obtained from special recombinant strains, i.e. B10.A(4R) and B10.A(5R), the authors were able to locate the gene that codes for the suppressive T cell factor reactive only with relevant haplotype strains between I B and I C subregions. These results are most reasonably explained by the presence of a new subregion I J which is specialized in coding for the suppressive T cell factor as a different molecule from previously known Ia molecules.

Original languageEnglish (US)
Pages (from-to)713-725
Number of pages13
JournalJournal of Experimental Medicine
Volume144
Issue number3
StatePublished - 1976
Externally publishedYes

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Immunologic Suppressor Factors
Major Histocompatibility Complex
Antibody Formation
Genes
TCF Transcription Factors
Histocompatibility
antigen-specific helper factors
Haplotypes
B-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

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title = "Properties of the antigen specific suppressive T cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T cell factor in the H-2 histocompatibility complex",
abstract = "The locus of the gene that codes for the antigen specific suppressive T cell factor was determined to be in a new subregion 'I J' which locates between I B and I C subregions in the H 2 histocompatibility complex. This was shown by 2 different lines of evidence: the absorbing capacity for the suppressive T cell factor of several alloantisera against restricted I subregions did not correlate with their specificity for previously known Ia molecules which are coded for by genes in I A and I C subregions, but was associated with the specificity for the products of genes putatively present between I B and I C subregions. By the occurrence of special recombinant strains, i.e. B10.A(5R), B10.A(3R), B1O.S(9R), and B10.HTT, which differ with respect to the I J subregion, the authors were able to produce alloantisera which distinguish I J subregion gene products. The absorption studies using these special alloantisera directed to I J subregion clearly indicated that the suppressive T cell factor is a product of I J subregion gene(s), and that the molecule is distinct from known Ia molecules expressed on splenic B cells. Taking advantage of the fact that there is a strict histocompatibility requirement for the effective suppression between the donor and recipient strains of the suppressive T cell factor, the authors were able to determine the required identities of the genes in the H 2 complex existing among those present between I B and I C. Again, utilizing the T cell factors obtained from special recombinant strains, i.e. B10.A(4R) and B10.A(5R), the authors were able to locate the gene that codes for the suppressive T cell factor reactive only with relevant haplotype strains between I B and I C subregions. These results are most reasonably explained by the presence of a new subregion I J which is specialized in coding for the suppressive T cell factor as a different molecule from previously known Ia molecules.",
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T1 - Properties of the antigen specific suppressive T cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T cell factor in the H-2 histocompatibility complex

AU - Tada, T.

AU - Taniguchi, M.

AU - David, C. S.

PY - 1976

Y1 - 1976

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