Promotion of endogeneous remyelination in multiple sclerosis

Claudia F Lucchinetti, J. H. Noseworthy, M. Rodriguez

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Studies in both human and experimental models demonstrate that myelin repair occurs in the central nervous system and is a normal physiologic response to myelin injury. However, remyelination in MS is often incomplete and limited. The outcome of an actively demyelinating lesion depends on the balance between factors promoting myelin destruction and myelin repair. Experimental models of CNS demyelination provide on opportunity to investigate the morphologic, cellular and molecular mechanisms involved in remyelination. This review focuses on experiments using the Theiler's virus model of demylination which indicate that manipulation of the immune response has the potential to promote endogenous CNS remyelination and functional recovery in MS.

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
JournalMultiple Sclerosis
Volume3
Issue number2
StatePublished - Apr 1997

Fingerprint

Myelin Sheath
Multiple Sclerosis
Theoretical Models
Theilovirus
Demyelinating Diseases
Central Nervous System
Wounds and Injuries

Keywords

  • Demyelinating disease
  • Immunoglobulin
  • Remyelination
  • Theiler's virus

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Promotion of endogeneous remyelination in multiple sclerosis. / Lucchinetti, Claudia F; Noseworthy, J. H.; Rodriguez, M.

In: Multiple Sclerosis, Vol. 3, No. 2, 04.1997, p. 71-75.

Research output: Contribution to journalArticle

Lucchinetti, CF, Noseworthy, JH & Rodriguez, M 1997, 'Promotion of endogeneous remyelination in multiple sclerosis', Multiple Sclerosis, vol. 3, no. 2, pp. 71-75.
Lucchinetti, Claudia F ; Noseworthy, J. H. ; Rodriguez, M. / Promotion of endogeneous remyelination in multiple sclerosis. In: Multiple Sclerosis. 1997 ; Vol. 3, No. 2. pp. 71-75.
@article{0778ac3dc3f0482aaa64c4ba39d9e30e,
title = "Promotion of endogeneous remyelination in multiple sclerosis",
abstract = "Studies in both human and experimental models demonstrate that myelin repair occurs in the central nervous system and is a normal physiologic response to myelin injury. However, remyelination in MS is often incomplete and limited. The outcome of an actively demyelinating lesion depends on the balance between factors promoting myelin destruction and myelin repair. Experimental models of CNS demyelination provide on opportunity to investigate the morphologic, cellular and molecular mechanisms involved in remyelination. This review focuses on experiments using the Theiler's virus model of demylination which indicate that manipulation of the immune response has the potential to promote endogenous CNS remyelination and functional recovery in MS.",
keywords = "Demyelinating disease, Immunoglobulin, Remyelination, Theiler's virus",
author = "Lucchinetti, {Claudia F} and Noseworthy, {J. H.} and M. Rodriguez",
year = "1997",
month = "4",
language = "English (US)",
volume = "3",
pages = "71--75",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "2",

}

TY - JOUR

T1 - Promotion of endogeneous remyelination in multiple sclerosis

AU - Lucchinetti, Claudia F

AU - Noseworthy, J. H.

AU - Rodriguez, M.

PY - 1997/4

Y1 - 1997/4

N2 - Studies in both human and experimental models demonstrate that myelin repair occurs in the central nervous system and is a normal physiologic response to myelin injury. However, remyelination in MS is often incomplete and limited. The outcome of an actively demyelinating lesion depends on the balance between factors promoting myelin destruction and myelin repair. Experimental models of CNS demyelination provide on opportunity to investigate the morphologic, cellular and molecular mechanisms involved in remyelination. This review focuses on experiments using the Theiler's virus model of demylination which indicate that manipulation of the immune response has the potential to promote endogenous CNS remyelination and functional recovery in MS.

AB - Studies in both human and experimental models demonstrate that myelin repair occurs in the central nervous system and is a normal physiologic response to myelin injury. However, remyelination in MS is often incomplete and limited. The outcome of an actively demyelinating lesion depends on the balance between factors promoting myelin destruction and myelin repair. Experimental models of CNS demyelination provide on opportunity to investigate the morphologic, cellular and molecular mechanisms involved in remyelination. This review focuses on experiments using the Theiler's virus model of demylination which indicate that manipulation of the immune response has the potential to promote endogenous CNS remyelination and functional recovery in MS.

KW - Demyelinating disease

KW - Immunoglobulin

KW - Remyelination

KW - Theiler's virus

UR - http://www.scopus.com/inward/record.url?scp=0030611835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030611835&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 71

EP - 75

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

IS - 2

ER -