Promotion of endogeneous remyelination in multiple sclerosis

C. F. Lucchinetti, J. H. Noseworthy, M. Rodriguez

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Studies in both human and experimental models demonstrate that myelin repair occurs in the central nervous system and is a normal physiologic response to myelin injury. However, remyelination in MS is often incomplete and limited. The outcome of an actively demyelinating lesion depends on the balance between factors promoting myelin destruction and myelin repair. Experimental models of CNS demyelination provide on opportunity to investigate the morphologic, cellular and molecular mechanisms involved in remyelination. This review focuses on experiments using the Theiler's virus model of demylination which indicate that manipulation of the immune response has the potential to promote endogenous CNS remyelination and functional recovery in MS.

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
JournalMultiple Sclerosis
Volume3
Issue number2
DOIs
StatePublished - Apr 1997

Keywords

  • Demyelinating disease
  • Immunoglobulin
  • Remyelination
  • Theiler's virus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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