Abstract
CD34+ cells are haematopoietic stem cells used therapeutically in patients undergoing radiation or chemotherapy due to their regenerative potential and ability to restore the haematopoietic system. In animal models, CD34+ cells have been associated with therapeutic angiogenesis in response to ischaemia. Several trials have shown the potential safety and efficacy of CD34+ cell delivery in various cardiovascular diseases. Moreover, Phase III trials have now begun to explore the potential role of CD34+ cells in treatment of both myocardial and peripheral ischaemia. CD34+ cells have been shown to be safe and well-tolerated in the acute myocardial infarction (AMI), heart failure, and angina models. Several studies have suggested potential benefit of CD34+ cell therapy in patients with coronary microvascular disease as well. In this review, we will discuss the therapeutic potential of CD34+ cells, and describe the pertinent trials that have used autologous CD34+ cells in no-options refractory angina, AMI, and heart failure. Lastly, we will review the potential utility of autologous CD34+ cells in coronary endothelial and microvascular dysfunction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1424-1433 |
| Number of pages | 10 |
| Journal | Cardiovascular research |
| Volume | 116 |
| Issue number | 8 |
| DOIs | |
| State | Published - Jul 1 2020 |
Keywords
- Acute coronary syndromes
- CD34
- Cardiovascular diseases
- Coronary endothelial dysfunction
- Coronary microvascular dysfunction
- Endothelial progenitor cells
- Heart failure
- Refractory angina
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
- Physiology (medical)