Promiscuous Structural Variants Drive Myeloma Initiation and Progression

P. Leif Bergsagel; W. Michael Kuehl

doi:10.1158/2643-3230.BCD-20-0170

Promiscuous Structural Variants Drive Myeloma Initiation and Progression

P. Leif Bergsagel, W. Michael Kuehl

Hematology/Oncology

Research output: Contribution to journal › Review article › peer-review

Abstract

A comprehensive genomic analysis of structural variants in multiple myeloma in this issue highlights the key role of these events, involving primarily the immunoglobulin heavy chain locus in disease initiation and the MYC locus in disease progression. However, the current study reveals the large number of genomic hotspots, oncogenes, tumor suppressor genes, and recombination mechanisms that contribute to multiple myeloma heterogeneity.

Original language	English (US)
Pages (from-to)	221-223
Number of pages	3
Journal	Blood cancer discovery
Volume	1
Issue number	3
DOIs	https://doi.org/10.1158/2643-3230.BCD-20-0170
State	Published - Nov 1 2020

ASJC Scopus subject areas

General Medicine

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10.1158/2643-3230.BCD-20-0170

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title = "Promiscuous Structural Variants Drive Myeloma Initiation and Progression",

abstract = "A comprehensive genomic analysis of structural variants in multiple myeloma in this issue highlights the key role of these events, involving primarily the immunoglobulin heavy chain locus in disease initiation and the MYC locus in disease progression. However, the current study reveals the large number of genomic hotspots, oncogenes, tumor suppressor genes, and recombination mechanisms that contribute to multiple myeloma heterogeneity.",

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Promiscuous Structural Variants Drive Myeloma Initiation and Progression

Abstract

ASJC Scopus subject areas

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