TY - JOUR
T1 - Promiscuous Structural Variants Drive Myeloma Initiation and Progression
AU - Bergsagel, P. Leif
AU - Kuehl, W. Michael
N1 - Publisher Copyright:
©2020 American Association for Cancer Research.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - A comprehensive genomic analysis of structural variants in multiple myeloma in this issue highlights the key role of these events, involving primarily the immunoglobulin heavy chain locus in disease initiation and the MYC locus in disease progression. However, the current study reveals the large number of genomic hotspots, oncogenes, tumor suppressor genes, and recombination mechanisms that contribute to multiple myeloma heterogeneity. See related article by Rustad et al., p. 258.
AB - A comprehensive genomic analysis of structural variants in multiple myeloma in this issue highlights the key role of these events, involving primarily the immunoglobulin heavy chain locus in disease initiation and the MYC locus in disease progression. However, the current study reveals the large number of genomic hotspots, oncogenes, tumor suppressor genes, and recombination mechanisms that contribute to multiple myeloma heterogeneity. See related article by Rustad et al., p. 258.
UR - http://www.scopus.com/inward/record.url?scp=85131533951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85131533951&partnerID=8YFLogxK
U2 - 10.1158/2643-3230.BCD-20-0170
DO - 10.1158/2643-3230.BCD-20-0170
M3 - Comment/debate
C2 - 34661146
AN - SCOPUS:85131533951
SN - 2643-3249
VL - 1
SP - 221
EP - 223
JO - Blood cancer discovery
JF - Blood cancer discovery
IS - 3
ER -