Promiscuous Structural Variants Drive Myeloma Initiation and Progression

P. Leif Bergsagel, W. Michael Kuehl

Research output: Contribution to journalComment/debatepeer-review


A comprehensive genomic analysis of structural variants in multiple myeloma in this issue highlights the key role of these events, involving primarily the immunoglobulin heavy chain locus in disease initiation and the MYC locus in disease progression. However, the current study reveals the large number of genomic hotspots, oncogenes, tumor suppressor genes, and recombination mechanisms that contribute to multiple myeloma heterogeneity. See related article by Rustad et al., p. 258.

Original languageEnglish (US)
Pages (from-to)221-223
Number of pages3
JournalBlood cancer discovery
Issue number3
StatePublished - Nov 1 2020

ASJC Scopus subject areas

  • Medicine(all)


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