Prolonged refractory status epilepticus related to thrombotic thrombocytopenic purpura

Alexander Y. Zubkov, Alejandro A. Rabinstein, Edward M. Manno, Eelco F.M. Wijdicks

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Thrombotic thrombocytopenic purpura (TTP) is an extremely rare cause of status epilepticus. Review of literature demonstrated only four cases of brief status epilepticus (SE) associated with TTP. Case: We describe a young woman with yet incomplete neurological recovery after prolonged refractory status epilepticus. Management required pentobarbital-induced coma for 60 days. Five months after onset, she was conversant and oriented with continued neuromuscular deficits. Conclusions: This is an unusual presentation of severe refractory SE associated with TTP. With aggressive life support and prolonged pentobarbital infusion, however, survival and the chance of meaningful recovery appear to be possible.

Original languageEnglish (US)
Pages (from-to)361-365
Number of pages5
JournalNeurocritical care
Volume9
Issue number3
DOIs
StatePublished - Dec 1 2008

Keywords

  • Status epilepticus
  • TTP

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine

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