Prolonged hypouricemia associated with acute chlorprothixene ingestion

Richard M Weinshilboum, J. L. Goldstein, W. N. Kelley

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Chlorprothixene (Taractan) is a tranquilizing drug used in the treatment of schizophrenia and agitated states. When given in therapeutic doses, chlorprothixene has been reported to lower the serum urate concentration in man by increasing the renal clearance of uric acid. The authors have observed a patient with prolonged hypouricemia and an increased urinary clearance of uric acid associated with an acute drug ingestion of a nearly fatal dose of chlorprothixene. The hypouricemia in their patient persisted for nearly 3 weeks and was associated with a transient aminoaciduria. These findings suggest that chlorprothixene, in large doses, may have a toxic effect on the proximal tubule in man.

Original languageEnglish (US)
Pages (from-to)739-741
Number of pages3
JournalArthritis and Rheumatism
Volume18
Issue number6 ,sup.
StatePublished - 1975

Fingerprint

Chlorprothixene
Eating
Uric Acid
Tranquilizing Agents
Poisons
Schizophrenia
Kidney
Therapeutics
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Prolonged hypouricemia associated with acute chlorprothixene ingestion. / Weinshilboum, Richard M; Goldstein, J. L.; Kelley, W. N.

In: Arthritis and Rheumatism, Vol. 18, No. 6 ,sup., 1975, p. 739-741.

Research output: Contribution to journalArticle

Weinshilboum, RM, Goldstein, JL & Kelley, WN 1975, 'Prolonged hypouricemia associated with acute chlorprothixene ingestion', Arthritis and Rheumatism, vol. 18, no. 6 ,sup., pp. 739-741.
Weinshilboum, Richard M ; Goldstein, J. L. ; Kelley, W. N. / Prolonged hypouricemia associated with acute chlorprothixene ingestion. In: Arthritis and Rheumatism. 1975 ; Vol. 18, No. 6 ,sup. pp. 739-741.
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