TY - JOUR
T1 - Prolonged high-dose isoflurane for refractory status epilepticus
T2 - Is it safe?
AU - Fugate, Jennifer E.
AU - Burns, Joseph D.
AU - Wijdicks, Eelco F.M.
AU - Warner, David O.
AU - Jankowski, Christopher J.
AU - Rabinstein, Alejandro A.
PY - 2010/12
Y1 - 2010/12
N2 - Isoflurane is an alternative treatment for refractory status epilepticus. Little is known regarding human toxicities caused by isoflurane. We present 2 patients with prolonged refractory status epilepticus treated with high concentrations of isoflurane who developed signal abnormalities on magnetic resonance imaging. Patient 1 was treated with isoflurane for 85 days with 1975.2% concentration-hours. Patient 2 was treated with isoflurane for 34 days with 1382.4% concentration-hours. Serial brain magnetic resonance images in both showed progressive T2 signal hyperintensity involving thalamus and cerebellum, which improved after discontinuation of isoflurane. These cases suggest that isoflurane may be neurotoxic when used in high doses for long time periods.
AB - Isoflurane is an alternative treatment for refractory status epilepticus. Little is known regarding human toxicities caused by isoflurane. We present 2 patients with prolonged refractory status epilepticus treated with high concentrations of isoflurane who developed signal abnormalities on magnetic resonance imaging. Patient 1 was treated with isoflurane for 85 days with 1975.2% concentration-hours. Patient 2 was treated with isoflurane for 34 days with 1382.4% concentration-hours. Serial brain magnetic resonance images in both showed progressive T2 signal hyperintensity involving thalamus and cerebellum, which improved after discontinuation of isoflurane. These cases suggest that isoflurane may be neurotoxic when used in high doses for long time periods.
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U2 - 10.1213/ANE.0b013e3181f6da34
DO - 10.1213/ANE.0b013e3181f6da34
M3 - Article
C2 - 20841413
AN - SCOPUS:78650303461
SN - 0003-2999
VL - 111
SP - 1520
EP - 1524
JO - Anesthesia and analgesia
JF - Anesthesia and analgesia
IS - 6
ER -