Prolonged E55+ retrovirus expression in aged mice is associated with a decline in the anti-virus immune response

Mohamed ElRefaei, Kenneth J. Blank, Donna M. Murasko

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

E55+ murine leukemia retrovirus (E55+ MuLV) infection of young and aged C57BL/6 (B6) mice was used to investigate the relationship between increased incidences of infection and decreased immune responsiveness of elderly individuals. Young mice decreased E55+MuLV burden to below detectable levels by 8 weeks postinfection (p.i.). In contrast, virus burden in aged mice did not reach undetectable levels until 20 weeks p.i. A significant T cell proliferative response to E55+ MuLV was detected from 2 to 12 weeks p.i. in young mice, but was never observed in aged mice. Both age groups demonstrated significant E55+MuLV-specific T-cell-mediated cytotoxic responses at 3 and 4 weeks p.i. and virus neutralizing antibody titers at 2, 4, 8, and 12 weeks p.i. In both cases, responses were consistently higher in young mice (P < 0.04 and P < 0.02, respectively). These results demonstrate that the observed delay in E55+MuLV clearance by aged mice is associated with an age-related decrease in the immune response to the virus.

Original languageEnglish (US)
Pages (from-to)281-289
Number of pages9
JournalVirology
Volume290
Issue number2
DOIs
StatePublished - Nov 25 2001

Keywords

  • Aging
  • CD4 T cell
  • CD8 T cell
  • Neutralizing antibody
  • Retrovirus

ASJC Scopus subject areas

  • Virology

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