Prolonged ambulatory monitoring of colonic motor activity in the pig

M. D. Crowell, F. Musial, W. French, D. Kittur, D. Anderson, W. E. Whitehead

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The aim of this study was to develop a chronic model suitable for repeated, long-term studies of the interaction of behavior and colonic function in unrestrained pigs. Cecostomies were created in three 20-30 kg micropigs under general anesthesia. Fistulas were created by suturing the bowel to the abdominal wall. Recordings were made by passing a small (8F) solid-state pressure transducer through the fistula into the proximal bowel and connecting it to a battery-operated data logger worn in a vest on the pig's back. Cecostomies have remained patent and trouble-free for over 18 months. No serious infections have occurred. Preliminary data from a total of thirteen 24-h recording sessions showed 54% of all contractile activity to be in the 2-4 cpm frequency range. Increased motility was seen following meals and upon morning awakening. Motility was minimal during the night. Infrequent (10.31 ± 2.05/24 h; mean ± SD) propagated contractions were also noted. These contractions were generally of low amplitude (33.24 ± 3.81 mmHg). These techniques allow prolonged, intraluminal recordings to be made from the colon of the unrestrained pig.

Original languageEnglish (US)
Pages (from-to)471-474
Number of pages4
JournalPhysiology and Behavior
Volume52
Issue number3
DOIs
StatePublished - Sep 1992

Keywords

  • Ambulatory monitoring
  • Motility
  • Pigs
  • Prolonged recording

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Prolonged ambulatory monitoring of colonic motor activity in the pig'. Together they form a unique fingerprint.

  • Cite this

    Crowell, M. D., Musial, F., French, W., Kittur, D., Anderson, D., & Whitehead, W. E. (1992). Prolonged ambulatory monitoring of colonic motor activity in the pig. Physiology and Behavior, 52(3), 471-474. https://doi.org/10.1016/0031-9384(92)90332-V