Proliferative glomerulonephritis due to monoclonal deposition with organized substructures

Abdurrahman M. Hamadah, Mira Keddis, Lynn D. Cornell, Nelson Leung

Research output: Contribution to journalArticle

Abstract

A growing number of monoclonal gammopathy-associated kidney diseases recently have been recognized. We present the case of a 54-year-old man who presented with acute kidney injury and hypocomplementemia. Kidney biopsy confirmed the presence of immunoglobulin G κ pseudothrombi with intracytoplasmic crystals in glomeruli and tubules. Levels of κ free light chains were elevated without a detectable monoclonal gammopathy, and bone marrow biopsy results were normal. After the first course of rituximab, cyclophosphamide, and dexamethasone in addition to daily plasmapheresis, kidney function recovered within 2 weeks and dialysis therapy was discontinued. Treatment for monoclonal protein-induced kidney disease should be considered in the setting of progressive decreased kidney function, even in the absence of a circulating monoclonal protein or cellular clone of origin.

Original languageEnglish (US)
Pages (from-to)994-998
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume64
Issue number6
DOIs
StatePublished - Dec 1 2014

Fingerprint

Glomerulonephritis
Paraproteinemias
Kidney Diseases
Kidney
Biopsy
Plasmapheresis
Acute Kidney Injury
Cyclophosphamide
Dexamethasone
Dialysis
Proteins
Clone Cells
Immunoglobulin G
Bone Marrow
Light
Therapeutics

Keywords

  • glomerulonephritis
  • Kidney failure
  • monoclonal protein

ASJC Scopus subject areas

  • Nephrology
  • Medicine(all)

Cite this

Proliferative glomerulonephritis due to monoclonal deposition with organized substructures. / Hamadah, Abdurrahman M.; Keddis, Mira; Cornell, Lynn D.; Leung, Nelson.

In: American Journal of Kidney Diseases, Vol. 64, No. 6, 01.12.2014, p. 994-998.

Research output: Contribution to journalArticle

Hamadah, Abdurrahman M. ; Keddis, Mira ; Cornell, Lynn D. ; Leung, Nelson. / Proliferative glomerulonephritis due to monoclonal deposition with organized substructures. In: American Journal of Kidney Diseases. 2014 ; Vol. 64, No. 6. pp. 994-998.
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