Proliferating cell nuclear antigen in epithelial ovarian cancer: Relation to results at second-look laparotomy and survival

Lynn C. Hartmann, Thomas J. Sebo, Nermeen A. Kamel, Karl C. Podratz, Stephen S. Cha, Harry S. Wieand, Gary L. Keeney, Patrick C. Roche

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

We determined the proliferative index (PI) of 92 previously untreated advanced epithelial ovarian cancers using PCNA/cyclin immunostaining and image analysis quantitation. In this retrospective study, there was a relationship between tumor PI and 5-year survival. For patients with a tumor PI greater than the median, the estimated 5-year survival was 44%; for patients with a tumor PI below the median, the estimated 5-year survival was 15% (P = 0.003). This may partly reflect sensitivity to chemotherapy, as those patients with more rapidly proliferating tumors were more likely to achieve a pathologic complete response to platinum-based therapy.

Original languageEnglish (US)
Pages (from-to)191-195
Number of pages5
JournalGynecologic oncology
Volume47
Issue number2
DOIs
StatePublished - Nov 1992

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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