Abstract
We determined the proliferative index (PI) of 92 previously untreated advanced epithelial ovarian cancers using PCNA/cyclin immunostaining and image analysis quantitation. In this retrospective study, there was a relationship between tumor PI and 5-year survival. For patients with a tumor PI greater than the median, the estimated 5-year survival was 44%; for patients with a tumor PI below the median, the estimated 5-year survival was 15% (P = 0.003). This may partly reflect sensitivity to chemotherapy, as those patients with more rapidly proliferating tumors were more likely to achieve a pathologic complete response to platinum-based therapy.
Original language | English (US) |
---|---|
Pages (from-to) | 191-195 |
Number of pages | 5 |
Journal | Gynecologic oncology |
Volume | 47 |
Issue number | 2 |
DOIs | |
State | Published - Nov 1992 |
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynecology