Prolactin suppression of leukocyte chemotaxis in vitro

R. D. Harris, Neil Elliot Kay, E. L. Seljeskog, K. J. Murray, S. D. Douglas

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Leukocyte chemotaxis in vitro was studied for cells from patients with pituitary adenomas. Leukocytes obtained preoperatively from two of three patients with elevated serum prolactin levels demonstrated chemotaxic alterations described in other malignant disease. Statistically significant suppression of chemotaxis occurred in the leukocytes of four of 12 specimens from normal donors at concentrations of 1000 ng/ml, and in four of eight specimens at 2000 ng/ml of prolactin in preincubation media. Thus prolactin concentration may influence the motility of leukocytes. The variable neoplastic behavior of morphologically similar pituitary adenomas may, in part, reflect a neurohormonally altered host response to the presence of these lesions.

Original languageEnglish (US)
Pages (from-to)462-465
Number of pages4
JournalJournal of Neurosurgery
Volume50
Issue number4
StatePublished - 1979
Externally publishedYes

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Leukocyte Chemotaxis
Prolactin
Leukocytes
Pituitary Neoplasms
Chemotaxis
Tissue Donors
Serum
In Vitro Techniques

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Harris, R. D., Kay, N. E., Seljeskog, E. L., Murray, K. J., & Douglas, S. D. (1979). Prolactin suppression of leukocyte chemotaxis in vitro. Journal of Neurosurgery, 50(4), 462-465.

Prolactin suppression of leukocyte chemotaxis in vitro. / Harris, R. D.; Kay, Neil Elliot; Seljeskog, E. L.; Murray, K. J.; Douglas, S. D.

In: Journal of Neurosurgery, Vol. 50, No. 4, 1979, p. 462-465.

Research output: Contribution to journalArticle

Harris, RD, Kay, NE, Seljeskog, EL, Murray, KJ & Douglas, SD 1979, 'Prolactin suppression of leukocyte chemotaxis in vitro', Journal of Neurosurgery, vol. 50, no. 4, pp. 462-465.
Harris RD, Kay NE, Seljeskog EL, Murray KJ, Douglas SD. Prolactin suppression of leukocyte chemotaxis in vitro. Journal of Neurosurgery. 1979;50(4):462-465.
Harris, R. D. ; Kay, Neil Elliot ; Seljeskog, E. L. ; Murray, K. J. ; Douglas, S. D. / Prolactin suppression of leukocyte chemotaxis in vitro. In: Journal of Neurosurgery. 1979 ; Vol. 50, No. 4. pp. 462-465.
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