Prolactin serum levels and breast cancer

Relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case-control study from Poland

J. M. Faupel-Badger, Mark E. Sherman, M. Garcia-Closas, M. M. Gaudet, R. T. Falk, A. Andaya, R. M. Pfeiffer, X. R. Yang, J. Lissowska, L. A. Brinton, B. Peplonska, B. K. Vonderhaar, J. D. Figueroa

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background:Previous prospective studies have found an association between prolactin (PRL) levels and increased risk of breast cancer. Using data from a population-based breast cancer case-control study conducted in two cities in Poland (2000-2003), we examined the association of PRL levels with breast cancer risk factors among controls and with tumour characteristics among the cases.Methods:We analysed PRL serum levels among 773 controls without breast cancer matched on age and residence to 776 invasive breast cancer cases with available pretreatment serum. Tumours were centrally reviewed and prepared as tissue microarrays for immunohistochemical analysis. Breast cancer risk factors, assessed by interview, were related to serum PRL levels among controls using analysis of variance. Mean serum PRL levels by tumour characteristics are reported. These associations also were evaluated using polytomous logistic regression.Results:Prolactin levels were associated with nulliparity in premenopausal (P = 0.05) but not in postmenopausal women. Associations in postmenopausal women included an inverse association with increasing body mass index (P = 0.0008) and direct association with use of recent/current hormone therapy (P = 0.0006). In case-only analyses, higher PRL levels were more strongly associated with lobular compared with ductal carcinoma among postmenopausal women (P = 0.02). Levels were not different by tumour size, grade, node involvement or oestrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2 status.Conclusions:Our analysis demonstrates that PRL levels are higher among premenopausal nulliparous as compared with parous women. Among postmenopausal women, levels were higher among hormone users and lower among obese women. These results may have value in understanding the mechanisms underlying several breast cancer risk factor associations.

Original languageEnglish (US)
Pages (from-to)1097-1102
Number of pages6
JournalBritish Journal of Cancer
Volume103
Issue number7
DOIs
StatePublished - Sep 28 2010

Fingerprint

Poland
Prolactin
Case-Control Studies
Breast Neoplasms
Serum
Population
Neoplasms
Tissue Array Analysis
Hormones
Ductal Carcinoma
Progesterone Receptors
Parity
Estrogen Receptors
Analysis of Variance
Body Mass Index
Logistic Models
Prospective Studies
Interviews

Keywords

  • breast cancer
  • lobular carcinoma
  • molecular subtypes
  • prolactin

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

Prolactin serum levels and breast cancer : Relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case-control study from Poland. / Faupel-Badger, J. M.; Sherman, Mark E.; Garcia-Closas, M.; Gaudet, M. M.; Falk, R. T.; Andaya, A.; Pfeiffer, R. M.; Yang, X. R.; Lissowska, J.; Brinton, L. A.; Peplonska, B.; Vonderhaar, B. K.; Figueroa, J. D.

In: British Journal of Cancer, Vol. 103, No. 7, 28.09.2010, p. 1097-1102.

Research output: Contribution to journalArticle

Faupel-Badger, JM, Sherman, ME, Garcia-Closas, M, Gaudet, MM, Falk, RT, Andaya, A, Pfeiffer, RM, Yang, XR, Lissowska, J, Brinton, LA, Peplonska, B, Vonderhaar, BK & Figueroa, JD 2010, 'Prolactin serum levels and breast cancer: Relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case-control study from Poland', British Journal of Cancer, vol. 103, no. 7, pp. 1097-1102. https://doi.org/10.1038/sj.bjc.6605844
Faupel-Badger, J. M. ; Sherman, Mark E. ; Garcia-Closas, M. ; Gaudet, M. M. ; Falk, R. T. ; Andaya, A. ; Pfeiffer, R. M. ; Yang, X. R. ; Lissowska, J. ; Brinton, L. A. ; Peplonska, B. ; Vonderhaar, B. K. ; Figueroa, J. D. / Prolactin serum levels and breast cancer : Relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case-control study from Poland. In: British Journal of Cancer. 2010 ; Vol. 103, No. 7. pp. 1097-1102.
@article{2ac827ba07af4369a736f9c9937223aa,
title = "Prolactin serum levels and breast cancer: Relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case-control study from Poland",
abstract = "Background:Previous prospective studies have found an association between prolactin (PRL) levels and increased risk of breast cancer. Using data from a population-based breast cancer case-control study conducted in two cities in Poland (2000-2003), we examined the association of PRL levels with breast cancer risk factors among controls and with tumour characteristics among the cases.Methods:We analysed PRL serum levels among 773 controls without breast cancer matched on age and residence to 776 invasive breast cancer cases with available pretreatment serum. Tumours were centrally reviewed and prepared as tissue microarrays for immunohistochemical analysis. Breast cancer risk factors, assessed by interview, were related to serum PRL levels among controls using analysis of variance. Mean serum PRL levels by tumour characteristics are reported. These associations also were evaluated using polytomous logistic regression.Results:Prolactin levels were associated with nulliparity in premenopausal (P = 0.05) but not in postmenopausal women. Associations in postmenopausal women included an inverse association with increasing body mass index (P = 0.0008) and direct association with use of recent/current hormone therapy (P = 0.0006). In case-only analyses, higher PRL levels were more strongly associated with lobular compared with ductal carcinoma among postmenopausal women (P = 0.02). Levels were not different by tumour size, grade, node involvement or oestrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2 status.Conclusions:Our analysis demonstrates that PRL levels are higher among premenopausal nulliparous as compared with parous women. Among postmenopausal women, levels were higher among hormone users and lower among obese women. These results may have value in understanding the mechanisms underlying several breast cancer risk factor associations.",
keywords = "breast cancer, lobular carcinoma, molecular subtypes, prolactin",
author = "Faupel-Badger, {J. M.} and Sherman, {Mark E.} and M. Garcia-Closas and Gaudet, {M. M.} and Falk, {R. T.} and A. Andaya and Pfeiffer, {R. M.} and Yang, {X. R.} and J. Lissowska and Brinton, {L. A.} and B. Peplonska and Vonderhaar, {B. K.} and Figueroa, {J. D.}",
year = "2010",
month = "9",
day = "28",
doi = "10.1038/sj.bjc.6605844",
language = "English (US)",
volume = "103",
pages = "1097--1102",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Prolactin serum levels and breast cancer

T2 - Relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case-control study from Poland

AU - Faupel-Badger, J. M.

AU - Sherman, Mark E.

AU - Garcia-Closas, M.

AU - Gaudet, M. M.

AU - Falk, R. T.

AU - Andaya, A.

AU - Pfeiffer, R. M.

AU - Yang, X. R.

AU - Lissowska, J.

AU - Brinton, L. A.

AU - Peplonska, B.

AU - Vonderhaar, B. K.

AU - Figueroa, J. D.

PY - 2010/9/28

Y1 - 2010/9/28

N2 - Background:Previous prospective studies have found an association between prolactin (PRL) levels and increased risk of breast cancer. Using data from a population-based breast cancer case-control study conducted in two cities in Poland (2000-2003), we examined the association of PRL levels with breast cancer risk factors among controls and with tumour characteristics among the cases.Methods:We analysed PRL serum levels among 773 controls without breast cancer matched on age and residence to 776 invasive breast cancer cases with available pretreatment serum. Tumours were centrally reviewed and prepared as tissue microarrays for immunohistochemical analysis. Breast cancer risk factors, assessed by interview, were related to serum PRL levels among controls using analysis of variance. Mean serum PRL levels by tumour characteristics are reported. These associations also were evaluated using polytomous logistic regression.Results:Prolactin levels were associated with nulliparity in premenopausal (P = 0.05) but not in postmenopausal women. Associations in postmenopausal women included an inverse association with increasing body mass index (P = 0.0008) and direct association with use of recent/current hormone therapy (P = 0.0006). In case-only analyses, higher PRL levels were more strongly associated with lobular compared with ductal carcinoma among postmenopausal women (P = 0.02). Levels were not different by tumour size, grade, node involvement or oestrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2 status.Conclusions:Our analysis demonstrates that PRL levels are higher among premenopausal nulliparous as compared with parous women. Among postmenopausal women, levels were higher among hormone users and lower among obese women. These results may have value in understanding the mechanisms underlying several breast cancer risk factor associations.

AB - Background:Previous prospective studies have found an association between prolactin (PRL) levels and increased risk of breast cancer. Using data from a population-based breast cancer case-control study conducted in two cities in Poland (2000-2003), we examined the association of PRL levels with breast cancer risk factors among controls and with tumour characteristics among the cases.Methods:We analysed PRL serum levels among 773 controls without breast cancer matched on age and residence to 776 invasive breast cancer cases with available pretreatment serum. Tumours were centrally reviewed and prepared as tissue microarrays for immunohistochemical analysis. Breast cancer risk factors, assessed by interview, were related to serum PRL levels among controls using analysis of variance. Mean serum PRL levels by tumour characteristics are reported. These associations also were evaluated using polytomous logistic regression.Results:Prolactin levels were associated with nulliparity in premenopausal (P = 0.05) but not in postmenopausal women. Associations in postmenopausal women included an inverse association with increasing body mass index (P = 0.0008) and direct association with use of recent/current hormone therapy (P = 0.0006). In case-only analyses, higher PRL levels were more strongly associated with lobular compared with ductal carcinoma among postmenopausal women (P = 0.02). Levels were not different by tumour size, grade, node involvement or oestrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2 status.Conclusions:Our analysis demonstrates that PRL levels are higher among premenopausal nulliparous as compared with parous women. Among postmenopausal women, levels were higher among hormone users and lower among obese women. These results may have value in understanding the mechanisms underlying several breast cancer risk factor associations.

KW - breast cancer

KW - lobular carcinoma

KW - molecular subtypes

KW - prolactin

UR - http://www.scopus.com/inward/record.url?scp=77957244403&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957244403&partnerID=8YFLogxK

U2 - 10.1038/sj.bjc.6605844

DO - 10.1038/sj.bjc.6605844

M3 - Article

VL - 103

SP - 1097

EP - 1102

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 7

ER -