Progressive systemic sclerosis associated with exposure to trichloroethylene

J. E. Lockey, C. R. Kelly, G. W. Cannon, T. V. Colby, V. Aldrich, G. K. Livingston

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Trichloroethylene (CHCL = CCL2) is a colorless aliphatic organic solvent with both historical use in medicine as an anesthetic agent and current use in industry as a degreasing agent. Although neither the etiology nor pathogenesis of progressive systemic sclerosis (scleroderma) has been established, this disease has been associated with a wide variety of seemingly unrelated compounds, including exposure to organic solvents. The authors describe a 47-year-old woman with previous excellent health who developed fatal progressive systemic sclerosis after a single 2.5-hour predominantly dermal exposure to trichloroethylene. During a period of 10 months the patient developed proximal scleroderma, reflux esophagitis, microangiopathic hemolytic anemia, restrictive pulmonary disease, pericarditis with effusion, and renal insufficiency with severe hypertension. Renal and skin biopsies were consistent with progressive systemic sclerosis.

Original languageEnglish (US)
Pages (from-to)493-496
Number of pages4
JournalJournal of Occupational Medicine
Volume29
Issue number6
StatePublished - 1987
Externally publishedYes

Fingerprint

Trichloroethylene
Diffuse Scleroderma
Peptic Esophagitis
Skin
Pericarditis
Systemic Scleroderma
Hemolytic Anemia
Lung Diseases
Renal Insufficiency
Anesthetics
Industry
Medicine
Hypertension
Kidney
Biopsy
Health

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Lockey, J. E., Kelly, C. R., Cannon, G. W., Colby, T. V., Aldrich, V., & Livingston, G. K. (1987). Progressive systemic sclerosis associated with exposure to trichloroethylene. Journal of Occupational Medicine, 29(6), 493-496.

Progressive systemic sclerosis associated with exposure to trichloroethylene. / Lockey, J. E.; Kelly, C. R.; Cannon, G. W.; Colby, T. V.; Aldrich, V.; Livingston, G. K.

In: Journal of Occupational Medicine, Vol. 29, No. 6, 1987, p. 493-496.

Research output: Contribution to journalArticle

Lockey, JE, Kelly, CR, Cannon, GW, Colby, TV, Aldrich, V & Livingston, GK 1987, 'Progressive systemic sclerosis associated with exposure to trichloroethylene', Journal of Occupational Medicine, vol. 29, no. 6, pp. 493-496.
Lockey JE, Kelly CR, Cannon GW, Colby TV, Aldrich V, Livingston GK. Progressive systemic sclerosis associated with exposure to trichloroethylene. Journal of Occupational Medicine. 1987;29(6):493-496.
Lockey, J. E. ; Kelly, C. R. ; Cannon, G. W. ; Colby, T. V. ; Aldrich, V. ; Livingston, G. K. / Progressive systemic sclerosis associated with exposure to trichloroethylene. In: Journal of Occupational Medicine. 1987 ; Vol. 29, No. 6. pp. 493-496.
@article{f3f5dcaa02514345b5fb87efc6237009,
title = "Progressive systemic sclerosis associated with exposure to trichloroethylene",
abstract = "Trichloroethylene (CHCL = CCL2) is a colorless aliphatic organic solvent with both historical use in medicine as an anesthetic agent and current use in industry as a degreasing agent. Although neither the etiology nor pathogenesis of progressive systemic sclerosis (scleroderma) has been established, this disease has been associated with a wide variety of seemingly unrelated compounds, including exposure to organic solvents. The authors describe a 47-year-old woman with previous excellent health who developed fatal progressive systemic sclerosis after a single 2.5-hour predominantly dermal exposure to trichloroethylene. During a period of 10 months the patient developed proximal scleroderma, reflux esophagitis, microangiopathic hemolytic anemia, restrictive pulmonary disease, pericarditis with effusion, and renal insufficiency with severe hypertension. Renal and skin biopsies were consistent with progressive systemic sclerosis.",
author = "Lockey, {J. E.} and Kelly, {C. R.} and Cannon, {G. W.} and Colby, {T. V.} and V. Aldrich and Livingston, {G. K.}",
year = "1987",
language = "English (US)",
volume = "29",
pages = "493--496",
journal = "Journal of Occupational and Environmental Medicine",
issn = "1076-2752",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Progressive systemic sclerosis associated with exposure to trichloroethylene

AU - Lockey, J. E.

AU - Kelly, C. R.

AU - Cannon, G. W.

AU - Colby, T. V.

AU - Aldrich, V.

AU - Livingston, G. K.

PY - 1987

Y1 - 1987

N2 - Trichloroethylene (CHCL = CCL2) is a colorless aliphatic organic solvent with both historical use in medicine as an anesthetic agent and current use in industry as a degreasing agent. Although neither the etiology nor pathogenesis of progressive systemic sclerosis (scleroderma) has been established, this disease has been associated with a wide variety of seemingly unrelated compounds, including exposure to organic solvents. The authors describe a 47-year-old woman with previous excellent health who developed fatal progressive systemic sclerosis after a single 2.5-hour predominantly dermal exposure to trichloroethylene. During a period of 10 months the patient developed proximal scleroderma, reflux esophagitis, microangiopathic hemolytic anemia, restrictive pulmonary disease, pericarditis with effusion, and renal insufficiency with severe hypertension. Renal and skin biopsies were consistent with progressive systemic sclerosis.

AB - Trichloroethylene (CHCL = CCL2) is a colorless aliphatic organic solvent with both historical use in medicine as an anesthetic agent and current use in industry as a degreasing agent. Although neither the etiology nor pathogenesis of progressive systemic sclerosis (scleroderma) has been established, this disease has been associated with a wide variety of seemingly unrelated compounds, including exposure to organic solvents. The authors describe a 47-year-old woman with previous excellent health who developed fatal progressive systemic sclerosis after a single 2.5-hour predominantly dermal exposure to trichloroethylene. During a period of 10 months the patient developed proximal scleroderma, reflux esophagitis, microangiopathic hemolytic anemia, restrictive pulmonary disease, pericarditis with effusion, and renal insufficiency with severe hypertension. Renal and skin biopsies were consistent with progressive systemic sclerosis.

UR - http://www.scopus.com/inward/record.url?scp=0023194088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023194088&partnerID=8YFLogxK

M3 - Article

C2 - 3612322

AN - SCOPUS:0023194088

VL - 29

SP - 493

EP - 496

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

SN - 1076-2752

IS - 6

ER -