TY - JOUR
T1 - Progressive supranuclear palsy
T2 - Phenotypic sex differences in a clinical cohort
AU - Baba, Yasuhiko
AU - Putzke, John D.
AU - Whaley, Nathaniel R.
AU - Wszolek, Zbigniew K.
AU - Uitti, Ryan J.
PY - 2006/5/1
Y1 - 2006/5/1
N2 - We examined sex-based differences in phenotypic expression among a consecutive clinical series of 121 individuals diagnosed with probable progressive supranuclear palsy (PSP). For both men (44%) and women (56%), the age at symptomatic onset (66.2 and 68.5 years, respectively) and disease duration (4.6 and 4.3 years, respectively) were similar. The overwhelming majority of sex-based comparisons showed no significant difference on a variety of demographic, historical, and clinical characteristics, as well as measures of disease progression. The only differences observed were that men had significantly worse tremor as measured by the Unified Parkinson's Disease Rating Scale tremor subscore (0.9 for men. and 0.3 for women, P < 0.01) and men had a significantly higher mean body mass index (BMI; 28.2 for men and 25.1 for women, P = 0.01), although these differences were not significant after Bonferroni correction. In general, the disease phenotype was similar between men and women, suggesting that sex may have little or no influence on the development, expression, or progression of the PSP phenotype.
AB - We examined sex-based differences in phenotypic expression among a consecutive clinical series of 121 individuals diagnosed with probable progressive supranuclear palsy (PSP). For both men (44%) and women (56%), the age at symptomatic onset (66.2 and 68.5 years, respectively) and disease duration (4.6 and 4.3 years, respectively) were similar. The overwhelming majority of sex-based comparisons showed no significant difference on a variety of demographic, historical, and clinical characteristics, as well as measures of disease progression. The only differences observed were that men had significantly worse tremor as measured by the Unified Parkinson's Disease Rating Scale tremor subscore (0.9 for men. and 0.3 for women, P < 0.01) and men had a significantly higher mean body mass index (BMI; 28.2 for men and 25.1 for women, P = 0.01), although these differences were not significant after Bonferroni correction. In general, the disease phenotype was similar between men and women, suggesting that sex may have little or no influence on the development, expression, or progression of the PSP phenotype.
KW - Body mass index (BMI)
KW - Clinical cohort
KW - Progressive supranuclear palsy (PSP)
KW - Sex
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U2 - 10.1002/mds.20769
DO - 10.1002/mds.20769
M3 - Article
C2 - 16342256
AN - SCOPUS:33646909370
VL - 21
SP - 689
EP - 692
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 5
ER -