Abstract
All cases examined postmortem at the Mayo Clinic that met the classic neuropathological criteria for progressive supranuclear palsy (PSP) were identified for retrospective clinical analyses. The necropsy material was re-examined by a second neuropathologist to confirm the pathological diagnosis of PSP, yielding 12 cases. A range of clinical signs were documented in these patients, with numerous findings beyond those noted in the original descriptions of this disorder. Atypical clinical findings included absence of supranuclear gaze palsy (two cases), prominent asymmetry (two), arm dystonia (two), upper limb apraxia (two), myoclonus (two), chorea (one), eyelid opening apraxia (one), and respiratory disturbance (one). A definite clinical diagnosis of PSP had been made during life in only eight of the 12 patients. From the retrospective analysis of these 12 cases a set of clinical criteria were developed for the premortem diagnosis of PSP emphasising differences from other akinetic-rigid disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 167-173 |
| Number of pages | 7 |
| Journal | Journal of Neurology Neurosurgery and Psychiatry |
| Volume | 58 |
| Issue number | 2 |
| State | Published - 1995 |
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Keywords
- Diagnostic criteria
- Neuropathology
- Progressive supranuclear palsy
ASJC Scopus subject areas
- Psychiatry and Mental health
- Neuroscience(all)
- Neuropsychology and Physiological Psychology
Cite this
Progressive supranuclear palsy : Neuropathologically based diagnostic clinical criteria. / Collins, S. J.; Ahlskog, J. E.; Parisi, Joseph E; Maraganore, D. M.
In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 58, No. 2, 1995, p. 167-173.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Progressive supranuclear palsy
T2 - Neuropathologically based diagnostic clinical criteria
AU - Collins, S. J.
AU - Ahlskog, J. E.
AU - Parisi, Joseph E
AU - Maraganore, D. M.
PY - 1995
Y1 - 1995
N2 - All cases examined postmortem at the Mayo Clinic that met the classic neuropathological criteria for progressive supranuclear palsy (PSP) were identified for retrospective clinical analyses. The necropsy material was re-examined by a second neuropathologist to confirm the pathological diagnosis of PSP, yielding 12 cases. A range of clinical signs were documented in these patients, with numerous findings beyond those noted in the original descriptions of this disorder. Atypical clinical findings included absence of supranuclear gaze palsy (two cases), prominent asymmetry (two), arm dystonia (two), upper limb apraxia (two), myoclonus (two), chorea (one), eyelid opening apraxia (one), and respiratory disturbance (one). A definite clinical diagnosis of PSP had been made during life in only eight of the 12 patients. From the retrospective analysis of these 12 cases a set of clinical criteria were developed for the premortem diagnosis of PSP emphasising differences from other akinetic-rigid disorders.
AB - All cases examined postmortem at the Mayo Clinic that met the classic neuropathological criteria for progressive supranuclear palsy (PSP) were identified for retrospective clinical analyses. The necropsy material was re-examined by a second neuropathologist to confirm the pathological diagnosis of PSP, yielding 12 cases. A range of clinical signs were documented in these patients, with numerous findings beyond those noted in the original descriptions of this disorder. Atypical clinical findings included absence of supranuclear gaze palsy (two cases), prominent asymmetry (two), arm dystonia (two), upper limb apraxia (two), myoclonus (two), chorea (one), eyelid opening apraxia (one), and respiratory disturbance (one). A definite clinical diagnosis of PSP had been made during life in only eight of the 12 patients. From the retrospective analysis of these 12 cases a set of clinical criteria were developed for the premortem diagnosis of PSP emphasising differences from other akinetic-rigid disorders.
KW - Diagnostic criteria
KW - Neuropathology
KW - Progressive supranuclear palsy
UR - http://www.scopus.com/inward/record.url?scp=0028969115&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028969115&partnerID=8YFLogxK
M3 - Article
C2 - 7876846
AN - SCOPUS:0028969115
VL - 58
SP - 167
EP - 173
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 2
ER -