Progressive Supranuclear Palsy in a family with TDP-43 pathology

A. Kertesz, E. Finger, J. Murrell, H. Chertkow, L. C. Ang, M. Baker, T. Ravenscroft, R. Rademakers, D. G. Munoz

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A member of a family with an autosomal dominant pattern of frontotemporal dementia (FTD) with a TDP-43 pathological substrate in other members and no mutations in FTD-associated genes developed behavioral variant FTD followed by Progressive Supranuclear Palsy. Autopsy revealed a pure tauopathy of PSP pattern. Conclusions: The findings raise the possibility of shared pathogenic pathways and a proximal genetic abnormality between PSP and FTLD-43.

Original languageEnglish (US)
Pages (from-to)178-184
Number of pages7
JournalNeurocase
Volume21
Issue number2
DOIs
StatePublished - Mar 4 2015

Keywords

  • Progressive Supranuclear Palsy
  • frontotemporal dementia
  • genetics

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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