Progressive neurological decline after partial spontaneous thrombosis of a Spetzler-Martin Grade 5 arteriovenous malformation in a patient with Leiden factor V mutation: Management and outcome. Case report

Michael J. Link, Thomas C. Schermerhorn, Jimmy R. Fulgham, Douglas A. Nichols

Research output: Contribution to journalArticle

4 Scopus citations


The coexistence of a large intracranial arteriovenous malformation (AVM) and a hypercoagulation disorder is rare. The AVM puts the patient at risk for progressive neurological deficit, seizures, and, most importantly, intracranial hemorrhage. The hypercoagulation disorder may result in an increased risk of stroke. The authors describe a 42-year-old man with a Spetzler-Martin Grade 5 AVM who experienced progressive neurological decline. He was subsequently discovered to have partial thrombosis of the AVM, deep cerebral and cortical venous thrombosis, and a hypercoagulation disorder. Hypercoagulation disorders causing neurological deficits are usually treated with anticoagulant medications; however, this approach was not thought to be safe in the presence of a large AVM. Therefore, the AVM nidus was surgically extirpated and a ventriculoperitoneal shunt was placed to treat the increased intracranial pressure caused by the cortical and deep cerebral venous thrombosis. Subsequently, lifelong oral anticoagulation was prescribed. The patient had a progressive neurological recovery and is now living independently at home. The occurrence of partial or complete spontaneous thrombosis of an AVM nidus should raise the possibility of an underlying hypercoagulation disorder.

Original languageEnglish (US)
Pages (from-to)940-945
Number of pages6
JournalJournal of neurosurgery
Issue number5
StatePublished - May 2004



  • Arteriovenous malformation
  • Hypercoagulation
  • Leiden factor V mutation
  • Thrombosis

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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