Progressive multifocal leukoencephalopathy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Progressive multifocal leukoencephalopathy (PML) is an opportunistic viral infection of the human central nervous system. It destroys oligodendrocytes leading to neurological deficits associated with demyelination. It most commonly occurs in HIV-infected patients, but increasing numbers of patients are being recognized in the context of immunosuppressive therapies for autoimmune diseases. The precise pathogenesis of infection by JC virus, a human papovavirus remains elusive, but much has been learned since the original description of the pathologic entity PML in 1958. Detection and diagnosis of this disorder has become more sophisticated with MR imaging of the brain and spinal fluid analysis using polymerase chain reaction (PCR) techniques. Immune reconstitution inflammatory syndrome complicates reversal of immunosuppression when PML has established a foothold in the brain. No effective therapy exists, but there is hope for both better management of patients diagnosed with exogenous immunosuppression and future prospects for antiviral therapy.

Original languageEnglish (US)
Title of host publicationViral Infections of the Human Nervous System
PublisherSpringer Basel
Pages65-86
Number of pages22
ISBN (Electronic)9783034804257
ISBN (Print)9783034804240
DOIs
StatePublished - Jan 1 2013

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Progressive Multifocal Leukoencephalopathy
Immunosuppression
Immune Reconstitution Inflammatory Syndrome
JC Virus
Opportunistic Infections
Oligodendroglia
Demyelinating Diseases
Virus Diseases
Immunosuppressive Agents
Neuroimaging
Autoimmune Diseases
Antiviral Agents
Therapeutics
Central Nervous System
HIV
Polymerase Chain Reaction
Brain
Infection

Keywords

  • Bizarre astrocytes
  • Immunosuppressive opportunistic infection
  • Inclusion bearing oligodendrocytes
  • IRIS
  • JC virus
  • PML
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Aksamit, A. J. (2013). Progressive multifocal leukoencephalopathy. In Viral Infections of the Human Nervous System (pp. 65-86). Springer Basel. https://doi.org/10.1007/978-3-0348-0425-7_4

Progressive multifocal leukoencephalopathy. / Aksamit, Allen Jr.

Viral Infections of the Human Nervous System. Springer Basel, 2013. p. 65-86.

Research output: Chapter in Book/Report/Conference proceedingChapter

Aksamit, AJ 2013, Progressive multifocal leukoencephalopathy. in Viral Infections of the Human Nervous System. Springer Basel, pp. 65-86. https://doi.org/10.1007/978-3-0348-0425-7_4
Aksamit AJ. Progressive multifocal leukoencephalopathy. In Viral Infections of the Human Nervous System. Springer Basel. 2013. p. 65-86 https://doi.org/10.1007/978-3-0348-0425-7_4
Aksamit, Allen Jr. / Progressive multifocal leukoencephalopathy. Viral Infections of the Human Nervous System. Springer Basel, 2013. pp. 65-86
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