Progressive Low-Grade Glioma: Assessment of Prognostic Importance of Histologic Reassessment and MRI Findings

Amol K. Narang, Kaisorn L. Chaichana, Jon D. Weingart, Kristin J. Redmond, Michael Lim, Alessandro Olivi, Alfredo Quinones-Hinojosa, Lawrence R. Kleinberg

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background In patients with progressive low-grade glioma (LGG), the presence of new magnetic resonance imaging (MRI) enhancement is commonly used as an indicator of malignant degeneration, but its accuracy in this setting is uncertain. Objective We characterize the ability of new MRI enhancement to serve as a surrogate for histologic grade in patients with progressive LGG, and to explore the prognostic value of new MRI enhancement, pathologic grade, and extent of resection. Methods Patients at our institution with World Health Organization grade II glioma diagnosed between 1994 and 2010 and who underwent repeat biopsy or resection at progression were retrospectively reviewed (n = 108). The positive predictive value, negative predictive value, sensitivity, and specificity of new MRI enhancement were characterized. A multivariable proportional hazards model was used to test associations with overall survival (OS), and Kaplan-Meier curves were constructed to compare OS between patient subsets. Results The positive predictive value, negative predictive value, sensitivity, and specificity of new MRI enhancement were 82%, 77%, 92%, and 57%, respectively. In patients without malignant degeneration, new MRI enhancement was associated with inferior median OS (92.5 months vs. not reached; P = 0.03). In patients with malignant degeneration, gross or near total resection was associated with improved median OS (58.8 vs. 28.8 months; P = 0.02). Conclusion In patients with progressive LGG, new MRI enhancement and pathologic grade were discordant in greater than 20% of cases. Pathologic confirmation of grade should therefore be attempted, when safe, to dictate management. Beyond functioning as a surrogate for pathologic grade, new MRI enhancement may predict for worse outcomes, a concept that merits prospective investigation.

Original languageEnglish (US)
Pages (from-to)751-757
Number of pages7
JournalWorld Neurosurgery
Volume99
DOIs
StatePublished - Mar 1 2017
Externally publishedYes

Keywords

  • Low-grade glioma
  • Malignant degeneration
  • MRI contrast enhancement
  • Progression

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Progressive Low-Grade Glioma: Assessment of Prognostic Importance of Histologic Reassessment and MRI Findings'. Together they form a unique fingerprint.

  • Cite this

    Narang, A. K., Chaichana, K. L., Weingart, J. D., Redmond, K. J., Lim, M., Olivi, A., Quinones-Hinojosa, A., & Kleinberg, L. R. (2017). Progressive Low-Grade Glioma: Assessment of Prognostic Importance of Histologic Reassessment and MRI Findings. World Neurosurgery, 99, 751-757. https://doi.org/10.1016/j.wneu.2016.04.030