Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy

Terence J. O'Brien; Elson L. So; Fredrick B. Meyer; Joseph E. Parisi; Clifford R. Jack

doi:10.1002/1531-8249(199904)45:4<526::AID-ANA17>3.0.CO;2-N

Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy

Terence J. O'Brien, Elson L. So, Fredrick B. Meyer, Joseph E. Parisi, Clifford R. Jack

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

We report on a 28-year-old man with long-standing intractable complex partial and secondary generalized seizures, whose magnetic resonance imaging scans 4 years apart documented progressive decrease in the left hippocampal volume. Left anterior temporal lobectomy with amygdalohippocampectomy rendered the patient seizure free at 12 months' follow-up. The findings demonstrate that patients with uncontrolled temporal lobe seizures may develop progressive atrophy of the hippocampus, in the absence of status epilepticus.

Original language	English (US)
Pages (from-to)	526-529
Number of pages	4
Journal	Annals of neurology
Volume	45
Issue number	4
DOIs	https://doi.org/10.1002/1531-8249(199904)45:4<526::AID-ANA17>3.0.CO;2-N
State	Published - 1999

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/1531-8249(199904)45:4<526::AID-ANA17>3.0.CO;2-N

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AU - So, Elson L.

AU - Meyer, Fredrick B.

AU - Parisi, Joseph E.

AU - Jack, Clifford R.

PY - 1999

Y1 - 1999

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AB - We report on a 28-year-old man with long-standing intractable complex partial and secondary generalized seizures, whose magnetic resonance imaging scans 4 years apart documented progressive decrease in the left hippocampal volume. Left anterior temporal lobectomy with amygdalohippocampectomy rendered the patient seizure free at 12 months' follow-up. The findings demonstrate that patients with uncontrolled temporal lobe seizures may develop progressive atrophy of the hippocampus, in the absence of status epilepticus.

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Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy

Abstract

ASJC Scopus subject areas

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