Progressive apraxia of speech and primary progressive aphasias

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Apraxia of speech (AOS) is a motor disorder that occurs as a result of impairment in the planning or programming of movements for speech production. It is typically associated with cerebrovascular events, although it can also occur in the context of neurodegeneration where its importance has typically been deemphasized to "just a component of a presenting syndrome." Primary progressive aphasia (PPA) is such a syndrome in which AOS coexists with other linguistic defi cits, typically agrammatic aphasia. Recently, however, AOS has been demonstrated to occur in a pure or isolated form, known as primary progressive apraxia of speech (PPAOS), reaffi rming the importance of neurodegenerative AOS. Furthermore, anatomic and pathologic associations differ between AOS-dominant syndromes and PPA variants. Understanding the relationship between AOS-dominant variants, including PPAOS and PPA, and their relationship to movement disorders including corticobasal degeneration and progressive supranuclear palsy, is important and will be the focus of this chapter.

Original languageEnglish (US)
Title of host publicationMovement Disorders in Dementias
PublisherSpringer-Verlag London Ltd
Pages213-230
Number of pages18
Volume9781447163657
ISBN (Print)9781447163657, 1447163648, 9781447163640
DOIs
StatePublished - Jan 1 2014

Keywords

  • Agrammatic aphasia
  • Apraxia of speech
  • Corticobasal degeneration
  • Primary progressive aphasia
  • Progressive supranuclear palsy
  • Tau

ASJC Scopus subject areas

  • Medicine(all)

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