Progressive aphasia in a patient with pick’s disease: A neuropsychological, radiologic, and anatomic study

N. R. Graff-Radford, A. R. Damasio, B. T. Hyman, M. N. Hart, D. Tranel, H. Damasio, G. W. Van Hoesen, K. Rezai

Research output: Contribution to journalArticle

162 Scopus citations

Abstract

Although Pick’s disease is generally considered as a dementia characterized by signs of frontal lobe dysfunction, it can present with selective language defects rather than with cognitive decline. In this study, we report prospective and serial clinical, neuropsychological, and neuroradiologic observations in a 59-year-old man whose prominent disturbance was in the retrieval and learning of names denoting concrete entities and actions. Postmortem study confirmed the diagnosis of Pick’s disease and revealed that neuronal loss and gliosis were most prominent in left anterior temporal cortices. The findings are in keeping with evidence that the left anterior temporal cortices and interconnected hippocampal system are critically involved in the learning and retrieval of verbal lexical items. The evidence from this patient, along with similar evidence from the literature we reviewed, suggests that when patients present with a progressive aphasia characterized by anomia, Pick’s disease should be considered as the probable diagnosis.

Original languageEnglish (US)
Pages (from-to)620-626
Number of pages7
JournalNeurology
Volume40
Issue number4
DOIs
StatePublished - Apr 1990

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Progressive aphasia in a patient with pick’s disease: A neuropsychological, radiologic, and anatomic study'. Together they form a unique fingerprint.

  • Cite this

    Graff-Radford, N. R., Damasio, A. R., Hyman, B. T., Hart, M. N., Tranel, D., Damasio, H., Van Hoesen, G. W., & Rezai, K. (1990). Progressive aphasia in a patient with pick’s disease: A neuropsychological, radiologic, and anatomic study. Neurology, 40(4), 620-626. https://doi.org/10.1212/wnl.40.4.620