TY - JOUR
T1 - Progressive aphasia in a patient with pick’s disease
T2 - A neuropsychological, radiologic, and anatomic study
AU - Graff-Radford, N. R.
AU - Damasio, A. R.
AU - Hyman, B. T.
AU - Hart, M. N.
AU - Tranel, D.
AU - Damasio, H.
AU - Van Hoesen, G. W.
AU - Rezai, K.
PY - 1990/4
Y1 - 1990/4
N2 - Although Pick’s disease is generally considered as a dementia characterized by signs of frontal lobe dysfunction, it can present with selective language defects rather than with cognitive decline. In this study, we report prospective and serial clinical, neuropsychological, and neuroradiologic observations in a 59-year-old man whose prominent disturbance was in the retrieval and learning of names denoting concrete entities and actions. Postmortem study confirmed the diagnosis of Pick’s disease and revealed that neuronal loss and gliosis were most prominent in left anterior temporal cortices. The findings are in keeping with evidence that the left anterior temporal cortices and interconnected hippocampal system are critically involved in the learning and retrieval of verbal lexical items. The evidence from this patient, along with similar evidence from the literature we reviewed, suggests that when patients present with a progressive aphasia characterized by anomia, Pick’s disease should be considered as the probable diagnosis.
AB - Although Pick’s disease is generally considered as a dementia characterized by signs of frontal lobe dysfunction, it can present with selective language defects rather than with cognitive decline. In this study, we report prospective and serial clinical, neuropsychological, and neuroradiologic observations in a 59-year-old man whose prominent disturbance was in the retrieval and learning of names denoting concrete entities and actions. Postmortem study confirmed the diagnosis of Pick’s disease and revealed that neuronal loss and gliosis were most prominent in left anterior temporal cortices. The findings are in keeping with evidence that the left anterior temporal cortices and interconnected hippocampal system are critically involved in the learning and retrieval of verbal lexical items. The evidence from this patient, along with similar evidence from the literature we reviewed, suggests that when patients present with a progressive aphasia characterized by anomia, Pick’s disease should be considered as the probable diagnosis.
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U2 - 10.1212/wnl.40.4.620
DO - 10.1212/wnl.40.4.620
M3 - Article
C2 - 2320235
AN - SCOPUS:0025319424
SN - 0028-3878
VL - 40
SP - 620
EP - 626
JO - Neurology
JF - Neurology
IS - 4
ER -