Progressive aphasia in a patient with Pick's disease: A neuropsychological, radiologic, and anatomic study

Neill R Graff Radford, A. R. Damasio, B. T. Hyman, M. N. Hart, D. Tranel, H. Damasio, G. W. Van Hoesen, K. Rezai

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

Although Pick's disease is generally considered as a dementia characterized by signs of frontal lobe dysfunction, it can present with selective language defects rather than with cognitive decline. In this study, we report prospective and serial clinical, neuropsychological, and neuroradiologic observations in a 59-year-old man whose prominent disturbance was in the retrieval and learning of names denoting concrete entities and actions. Postmortem study confirmed the diagnosis of Pick's disease and revealed that neuronal loss and gliosis were most prominent in left anterior temporal cortices. The findings are in keeping with evidence that the left anterior temporal cortices and interconnected hippocampal system are critically involved in the learning and retrieval of verbal lexical items. The evidence from this patient, along with similar evidence from the literature we reviewed, suggests that when patients present with a progressive aphasia characterized by anomia, Pick's disease should be considered as the probable diagnosis.

Original languageEnglish (US)
Pages (from-to)620-626
Number of pages7
JournalNeurology
Volume40
Issue number4
StatePublished - Apr 1990
Externally publishedYes

Fingerprint

Pick Disease of the Brain
Aphasia
Temporal Lobe
Anomia
Verbal Learning
Gliosis
Frontal Lobe
Names
Dementia
Language
Learning

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Graff Radford, N. R., Damasio, A. R., Hyman, B. T., Hart, M. N., Tranel, D., Damasio, H., ... Rezai, K. (1990). Progressive aphasia in a patient with Pick's disease: A neuropsychological, radiologic, and anatomic study. Neurology, 40(4), 620-626.

Progressive aphasia in a patient with Pick's disease : A neuropsychological, radiologic, and anatomic study. / Graff Radford, Neill R; Damasio, A. R.; Hyman, B. T.; Hart, M. N.; Tranel, D.; Damasio, H.; Van Hoesen, G. W.; Rezai, K.

In: Neurology, Vol. 40, No. 4, 04.1990, p. 620-626.

Research output: Contribution to journalArticle

Graff Radford, NR, Damasio, AR, Hyman, BT, Hart, MN, Tranel, D, Damasio, H, Van Hoesen, GW & Rezai, K 1990, 'Progressive aphasia in a patient with Pick's disease: A neuropsychological, radiologic, and anatomic study', Neurology, vol. 40, no. 4, pp. 620-626.
Graff Radford, Neill R ; Damasio, A. R. ; Hyman, B. T. ; Hart, M. N. ; Tranel, D. ; Damasio, H. ; Van Hoesen, G. W. ; Rezai, K. / Progressive aphasia in a patient with Pick's disease : A neuropsychological, radiologic, and anatomic study. In: Neurology. 1990 ; Vol. 40, No. 4. pp. 620-626.
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