Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type

Zeina S. Tannous, Lisa H. Lerner, Lyn M. Duncan, Martin C. Mihm, Thomas J Flotte

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We have previously hypothesized that lesions that have been termed lentigo maligna can be divided into 2 categories: 1 represents a pigmented lesion that is a precursor to melanoma, and the other melanoma in situ. We and others have hypothesized that there is a progressive acquisition of attributes in pigmented lesions that results in malignant melanoma. Based on these 2 hypotheses, we have predicted that the intraepidermal component of invasive malignant melanomas, lentigo maligna type, should be similar to those lesions that we have termed malignant melanoma in situ, lentigo maligna type rather than lentigo maligna. The intraepidermal component of 42 consecutive cases of invasive malignant melanoma, lentigo maligna type was evaluated by all of the authors. Malignant melanoma in situ, lentigo maligna type is characterized by pagetoid spread, confluence, and nesting of atypical melanocytes. All of thee cases evaluated showed features diagnostic of malignant melanoma in situ, lentigo maligna type, in the epidermis overlying the invasive dermal component. We conclude that invasive lentigo maligna melanoma arises in association with those lesions that we have termed malignant melanoma in situ, lentigo maligna type, which may represent a step in the progression between atypical melanocytic hyperplasia (lentigo maligna) and invasive melanoma. This finding supports the distinction of these entities and may have therapeutic implications. (C) 2000 by W. B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)705-708
Number of pages4
JournalHuman Pathology
Volume31
Issue number6
StatePublished - 2000
Externally publishedYes

Fingerprint

Hutchinson's Melanotic Freckle
Melanoma
Melanocytes
Epidermis
Hyperplasia

Keywords

  • Lentigo maligna
  • Lentigo maligna melanoma
  • Tumor Progression

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Tannous, Z. S., Lerner, L. H., Duncan, L. M., Mihm, M. C., & Flotte, T. J. (2000). Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type. Human Pathology, 31(6), 705-708.

Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type. / Tannous, Zeina S.; Lerner, Lisa H.; Duncan, Lyn M.; Mihm, Martin C.; Flotte, Thomas J.

In: Human Pathology, Vol. 31, No. 6, 2000, p. 705-708.

Research output: Contribution to journalArticle

Tannous, ZS, Lerner, LH, Duncan, LM, Mihm, MC & Flotte, TJ 2000, 'Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type', Human Pathology, vol. 31, no. 6, pp. 705-708.
Tannous, Zeina S. ; Lerner, Lisa H. ; Duncan, Lyn M. ; Mihm, Martin C. ; Flotte, Thomas J. / Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type. In: Human Pathology. 2000 ; Vol. 31, No. 6. pp. 705-708.
@article{920913bcd6aa42d2ab0eda5a9f181542,
title = "Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type",
abstract = "We have previously hypothesized that lesions that have been termed lentigo maligna can be divided into 2 categories: 1 represents a pigmented lesion that is a precursor to melanoma, and the other melanoma in situ. We and others have hypothesized that there is a progressive acquisition of attributes in pigmented lesions that results in malignant melanoma. Based on these 2 hypotheses, we have predicted that the intraepidermal component of invasive malignant melanomas, lentigo maligna type, should be similar to those lesions that we have termed malignant melanoma in situ, lentigo maligna type rather than lentigo maligna. The intraepidermal component of 42 consecutive cases of invasive malignant melanoma, lentigo maligna type was evaluated by all of the authors. Malignant melanoma in situ, lentigo maligna type is characterized by pagetoid spread, confluence, and nesting of atypical melanocytes. All of thee cases evaluated showed features diagnostic of malignant melanoma in situ, lentigo maligna type, in the epidermis overlying the invasive dermal component. We conclude that invasive lentigo maligna melanoma arises in association with those lesions that we have termed malignant melanoma in situ, lentigo maligna type, which may represent a step in the progression between atypical melanocytic hyperplasia (lentigo maligna) and invasive melanoma. This finding supports the distinction of these entities and may have therapeutic implications. (C) 2000 by W. B. Saunders Company.",
keywords = "Lentigo maligna, Lentigo maligna melanoma, Tumor Progression",
author = "Tannous, {Zeina S.} and Lerner, {Lisa H.} and Duncan, {Lyn M.} and Mihm, {Martin C.} and Flotte, {Thomas J}",
year = "2000",
language = "English (US)",
volume = "31",
pages = "705--708",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type

AU - Tannous, Zeina S.

AU - Lerner, Lisa H.

AU - Duncan, Lyn M.

AU - Mihm, Martin C.

AU - Flotte, Thomas J

PY - 2000

Y1 - 2000

N2 - We have previously hypothesized that lesions that have been termed lentigo maligna can be divided into 2 categories: 1 represents a pigmented lesion that is a precursor to melanoma, and the other melanoma in situ. We and others have hypothesized that there is a progressive acquisition of attributes in pigmented lesions that results in malignant melanoma. Based on these 2 hypotheses, we have predicted that the intraepidermal component of invasive malignant melanomas, lentigo maligna type, should be similar to those lesions that we have termed malignant melanoma in situ, lentigo maligna type rather than lentigo maligna. The intraepidermal component of 42 consecutive cases of invasive malignant melanoma, lentigo maligna type was evaluated by all of the authors. Malignant melanoma in situ, lentigo maligna type is characterized by pagetoid spread, confluence, and nesting of atypical melanocytes. All of thee cases evaluated showed features diagnostic of malignant melanoma in situ, lentigo maligna type, in the epidermis overlying the invasive dermal component. We conclude that invasive lentigo maligna melanoma arises in association with those lesions that we have termed malignant melanoma in situ, lentigo maligna type, which may represent a step in the progression between atypical melanocytic hyperplasia (lentigo maligna) and invasive melanoma. This finding supports the distinction of these entities and may have therapeutic implications. (C) 2000 by W. B. Saunders Company.

AB - We have previously hypothesized that lesions that have been termed lentigo maligna can be divided into 2 categories: 1 represents a pigmented lesion that is a precursor to melanoma, and the other melanoma in situ. We and others have hypothesized that there is a progressive acquisition of attributes in pigmented lesions that results in malignant melanoma. Based on these 2 hypotheses, we have predicted that the intraepidermal component of invasive malignant melanomas, lentigo maligna type, should be similar to those lesions that we have termed malignant melanoma in situ, lentigo maligna type rather than lentigo maligna. The intraepidermal component of 42 consecutive cases of invasive malignant melanoma, lentigo maligna type was evaluated by all of the authors. Malignant melanoma in situ, lentigo maligna type is characterized by pagetoid spread, confluence, and nesting of atypical melanocytes. All of thee cases evaluated showed features diagnostic of malignant melanoma in situ, lentigo maligna type, in the epidermis overlying the invasive dermal component. We conclude that invasive lentigo maligna melanoma arises in association with those lesions that we have termed malignant melanoma in situ, lentigo maligna type, which may represent a step in the progression between atypical melanocytic hyperplasia (lentigo maligna) and invasive melanoma. This finding supports the distinction of these entities and may have therapeutic implications. (C) 2000 by W. B. Saunders Company.

KW - Lentigo maligna

KW - Lentigo maligna melanoma

KW - Tumor Progression

UR - http://www.scopus.com/inward/record.url?scp=0033937121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033937121&partnerID=8YFLogxK

M3 - Article

VL - 31

SP - 705

EP - 708

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 6

ER -