TY - JOUR
T1 - Progression of primary biliary cirrhosis with ursodeoxycholic acid therapy
AU - Perdigoto, Rui
AU - Wiesner, Russell H.
PY - 1992/4
Y1 - 1992/4
N2 - Three patients with symptomatic, noncirrhotic primary biliary cirrhosis who had no evidence of esophageal varices on esophagogastroduodenoscopy and who were treated with ursodeoxycholic acid, 15 mg · kg-1 · day-1, for a period of 1-2 years are reported. Initially, all three patients showed improvement in symptoms of fatigue and pruritus, and there was marked improvement or normalization in serum levels of bilirubin, alkaline phosphatase, and alanine aminotransferase. However, after 1-2 years, all three patients progressed histologically to cirrhosis on follow-up liver biopsy, and all had esophageal variceal bleeding documented by esophagogastroduodenoscopy. These three patients represent examples of ursodeoxycholic acid treatment failure despite improvements in symptoms and biochemical liver test results.
AB - Three patients with symptomatic, noncirrhotic primary biliary cirrhosis who had no evidence of esophageal varices on esophagogastroduodenoscopy and who were treated with ursodeoxycholic acid, 15 mg · kg-1 · day-1, for a period of 1-2 years are reported. Initially, all three patients showed improvement in symptoms of fatigue and pruritus, and there was marked improvement or normalization in serum levels of bilirubin, alkaline phosphatase, and alanine aminotransferase. However, after 1-2 years, all three patients progressed histologically to cirrhosis on follow-up liver biopsy, and all had esophageal variceal bleeding documented by esophagogastroduodenoscopy. These three patients represent examples of ursodeoxycholic acid treatment failure despite improvements in symptoms and biochemical liver test results.
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U2 - 10.1016/0016-5085(92)70038-d
DO - 10.1016/0016-5085(92)70038-d
M3 - Article
C2 - 1551544
AN - SCOPUS:0026518805
SN - 0016-5085
VL - 102
SP - 1389
EP - 1391
JO - Gastroenterology
JF - Gastroenterology
IS - 4 PART 1
ER -