Progress in the Management of Malignant Pleural Mesothelioma in 2017

Amanda J. McCambridge, Andrea Napolitano, Aaron S. Mansfield, Dean A. Fennell, Yoshitaka Sekido, Anna K. Nowak, Thanyanan Reungwetwattana, Weimin Mao, Harvey I. Pass, Michele Carbone, Haining Yang, Tobias Peikert

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Malignant pleural mesothelioma (MPM) is an uncommon, almost universally fatal, asbestos-induced malignancy. New and effective strategies for diagnosis, prognostication, and treatment are urgently needed. Herein we review the advances in MPM achieved in 2017. Whereas recent epidemiological data demonstrated that the incidence of MPM-related death continued to increase in United States between 2009 and 2015, new insight into the molecular pathogenesis and the immunological tumor microenvironment of MPM, for example, regarding the role of BRCA1 associated protein 1 and the expression programmed death receptor ligand 1, are highlighting new potential therapeutic strategies. Furthermore, there continues to be an ever-expanding number of clinical studies investigating systemic therapies for MPM. These trials are primarily focused on immunotherapy using immune checkpoint inhibitors alone or in combination with other immunotherapies and nonimmunotherapies. In addition, other promising targeted therapies, including pegylated adenosine deiminase (ADI-PEG20), which focuses on argininosuccinate synthase 1–deficient tumors, and tazemetostat, an enhancer of zeste 2 polycomb repressive complex 2 subunit inhibitor of BRCA1 associated protein 1 gene (BAP1)-deficient tumors, are currently being explored.

Original languageEnglish (US)
Pages (from-to)606-623
Number of pages18
JournalJournal of Thoracic Oncology
Volume13
Issue number5
DOIs
StatePublished - May 2018

Keywords

  • BAP1
  • Immunotherapy
  • Mesothelin
  • Mesothelioma
  • Review
  • Therapy

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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  • Cite this

    McCambridge, A. J., Napolitano, A., Mansfield, A. S., Fennell, D. A., Sekido, Y., Nowak, A. K., Reungwetwattana, T., Mao, W., Pass, H. I., Carbone, M., Yang, H., & Peikert, T. (2018). Progress in the Management of Malignant Pleural Mesothelioma in 2017. Journal of Thoracic Oncology, 13(5), 606-623. https://doi.org/10.1016/j.jtho.2018.02.021