Progress in acid-sensing ion channels

Long Jun Wu, Tian Le Xu

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Tissue acidosis is a general phenomenon under physiological and pathological conditions. Through acid-sensing ion channels (ASICs), neuron can detect the drops in extracellular pH. ASICs are one of members of DEG/ENaC family. To date, six subunits of ASICs family have been identified. They are widely expressed in the peripheral and central nervous system. The homomers and heteromers channels of these subunits exhibit a variety of electrophysiological properties. ASICs play a critical role in several modalities of sensation, especially nociception.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalProgress in Biochemistry and Biophysics
Volume29
Issue number2
StatePublished - Apr 1 2002

Keywords

  • Acid-sensing ion channels (ASICs)
  • Nociception
  • Tissue acidosis

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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