Progress and Prospects: Genetic treatments for disorders of bones and joints

Christopher H Evans, S. C. Ghivizzani, P. D. Robbins

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Gene therapies directed toward the treatment of arthritis and tissue repair continue to be the most active areas of research for bone and joint diseases. In the past 2 years, two trials in rheumatoid arthritis have been completed. a Phase I study reporting safety and a Phase I/II study that has yet to be published. An additional, small study has reported the first evidence of clinical efficacy. Two Phase I trials of gene therapy for osteoarthritis have also been initiated. There is much preclinical activity in developing AAV vectors for future trials in the gene therapy of arthritis. Research into tissue repair and regeneration remains at the preclinical stage, but a considerable volume of research attests to the promise of gene transfer in this arena, especially in the context of bone healing. For tissue repair, the major research questions are still which genes to use and how best to deliver them.

Original languageEnglish (US)
Pages (from-to)944-952
Number of pages9
JournalGene Therapy
Volume16
Issue number8
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Inborn Genetic Diseases
Joints
Genetic Therapy
Bone and Bones
Research
Arthritis
Joint Diseases
Bone Diseases
Therapeutics
Osteoarthritis
Genes
Regeneration
Rheumatoid Arthritis
Safety

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

Cite this

Progress and Prospects : Genetic treatments for disorders of bones and joints. / Evans, Christopher H; Ghivizzani, S. C.; Robbins, P. D.

In: Gene Therapy, Vol. 16, No. 8, 2009, p. 944-952.

Research output: Contribution to journalArticle

Evans, Christopher H ; Ghivizzani, S. C. ; Robbins, P. D. / Progress and Prospects : Genetic treatments for disorders of bones and joints. In: Gene Therapy. 2009 ; Vol. 16, No. 8. pp. 944-952.
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