Progranulin in frontotemporal lobar degeneration and neuroinflammation

Zeshan Ahmed, Ian R A Mackenzie, Michael L. Hutton, Dennis W Dickson

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries of mutations in the gene for PGRN that cause frontotemporal lobar degeneration (FTLD). Pathogenic mutations in PGRN result in null alleles, and the disease is likely the result of haploinsufficiency. Little is known about the normal function of PGRN in the central nervous system apart from a role in brain development. It is expressed by microglia and neurons. In the periphery, PGRN is involved in wound repair and inflammation. High PGRN expression has been associated with more aggressive growth of various tumors. The properties of full length PGRN are distinct from those of proteolytically derived peptides, referred to as granulins (GRNs). While PGRN has trophic properties, GRNs are more akin to inflammatory mediators such as cytokines. Loss of the neurotrophic properties of PGRN may play a role in selective neuronal degeneration in FTLD, but neuroinflammation may also be important. Gene expression studies suggest that PGRN is up-regulated in a variety of neuroinflammatory conditions, and increased PGRN expression by microglia may play a pivotal role in the response to brain injury, neuroinflammation and neurodegeneration.

Original languageEnglish (US)
Article number7
JournalJournal of Neuroinflammation
Volume4
DOIs
StatePublished - 2007

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Frontotemporal Lobar Degeneration
Microglia
Haploinsufficiency
Mutation
Neurosciences
Brain Injuries
Central Nervous System
Alleles
Cytokines
Inflammation
Gene Expression
Neurons
Peptides
Wounds and Injuries
Brain
Growth
Genes
Neoplasms
Proteins
granulin precursor protein

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Progranulin in frontotemporal lobar degeneration and neuroinflammation. / Ahmed, Zeshan; Mackenzie, Ian R A; Hutton, Michael L.; Dickson, Dennis W.

In: Journal of Neuroinflammation, Vol. 4, 7, 2007.

Research output: Contribution to journalArticle

Ahmed, Zeshan ; Mackenzie, Ian R A ; Hutton, Michael L. ; Dickson, Dennis W. / Progranulin in frontotemporal lobar degeneration and neuroinflammation. In: Journal of Neuroinflammation. 2007 ; Vol. 4.
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