Programmed death-ligand 1 (PD-L1) may play a role in malignant glioma infiltration

Lei Zhang; Zhiqing Zhang; Yunhui Liu; Yixue Xue; Ian Parney

doi:10.1016/j.mehy.2015.04.009

Programmed death-ligand 1 (PD-L1) may play a role in malignant glioma infiltration

Lei Zhang, Zhiqing Zhang, Yunhui Liu, Yixue Xue, Ian Parney

Neurosurgery

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Infiltration is the main cause of death of malignant glioma patients. However, the mechanisms of the infiltration in the development of brain cancer (glioblastoma multiforme) are not completely understood. Here, we hypothesized that, in the development of human brain cancer, infiltration is primarily due to differentiated cancer cells and that the cell surface molecule programmed death-ligand 1 (PD-L1) may play an important role in brain tumor infiltration. PD-L1 is highly expressed in differentiated glioma cells in comparison to undifferentiated ones. As PD-L1 has both pro-survival and immunoinhibitory functions in tumor cells, the potential role of PD-L1 in tumor propagation suggest a new therapeutic target for preventing glioma infiltration and recurrence.

Original language	English (US)
Pages (from-to)	127-129
Number of pages	3
Journal	Medical Hypotheses
Volume	85
Issue number	2
DOIs	https://doi.org/10.1016/j.mehy.2015.04.009
State	Published - 2015

ASJC Scopus subject areas

Medicine(all)

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title = "Programmed death-ligand 1 (PD-L1) may play a role in malignant glioma infiltration",

abstract = "Infiltration is the main cause of death of malignant glioma patients. However, the mechanisms of the infiltration in the development of brain cancer (glioblastoma multiforme) are not completely understood. Here, we hypothesized that, in the development of human brain cancer, infiltration is primarily due to differentiated cancer cells and that the cell surface molecule programmed death-ligand 1 (PD-L1) may play an important role in brain tumor infiltration. PD-L1 is highly expressed in differentiated glioma cells in comparison to undifferentiated ones. As PD-L1 has both pro-survival and immunoinhibitory functions in tumor cells, the potential role of PD-L1 in tumor propagation suggest a new therapeutic target for preventing glioma infiltration and recurrence.",

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AU - Liu, Yunhui

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AU - Parney, Ian

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AB - Infiltration is the main cause of death of malignant glioma patients. However, the mechanisms of the infiltration in the development of brain cancer (glioblastoma multiforme) are not completely understood. Here, we hypothesized that, in the development of human brain cancer, infiltration is primarily due to differentiated cancer cells and that the cell surface molecule programmed death-ligand 1 (PD-L1) may play an important role in brain tumor infiltration. PD-L1 is highly expressed in differentiated glioma cells in comparison to undifferentiated ones. As PD-L1 has both pro-survival and immunoinhibitory functions in tumor cells, the potential role of PD-L1 in tumor propagation suggest a new therapeutic target for preventing glioma infiltration and recurrence.

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