Abstract
Infiltration is the main cause of death of malignant glioma patients. However, the mechanisms of the infiltration in the development of brain cancer (glioblastoma multiforme) are not completely understood. Here, we hypothesized that, in the development of human brain cancer, infiltration is primarily due to differentiated cancer cells and that the cell surface molecule programmed death-ligand 1 (PD-L1) may play an important role in brain tumor infiltration. PD-L1 is highly expressed in differentiated glioma cells in comparison to undifferentiated ones. As PD-L1 has both pro-survival and immunoinhibitory functions in tumor cells, the potential role of PD-L1 in tumor propagation suggest a new therapeutic target for preventing glioma infiltration and recurrence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 127-129 |
| Number of pages | 3 |
| Journal | Medical Hypotheses |
| Volume | 85 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2015 |
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ASJC Scopus subject areas
- Medicine(all)
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Programmed death-ligand 1 (PD-L1) may play a role in malignant glioma infiltration. / Zhang, Lei; Zhang, Zhiqing; Liu, Yunhui; Xue, Yixue; Parney, Ian F.
In: Medical Hypotheses, Vol. 85, No. 2, 2015, p. 127-129.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Programmed death-ligand 1 (PD-L1) may play a role in malignant glioma infiltration
AU - Zhang, Lei
AU - Zhang, Zhiqing
AU - Liu, Yunhui
AU - Xue, Yixue
AU - Parney, Ian F
PY - 2015
Y1 - 2015
N2 - Infiltration is the main cause of death of malignant glioma patients. However, the mechanisms of the infiltration in the development of brain cancer (glioblastoma multiforme) are not completely understood. Here, we hypothesized that, in the development of human brain cancer, infiltration is primarily due to differentiated cancer cells and that the cell surface molecule programmed death-ligand 1 (PD-L1) may play an important role in brain tumor infiltration. PD-L1 is highly expressed in differentiated glioma cells in comparison to undifferentiated ones. As PD-L1 has both pro-survival and immunoinhibitory functions in tumor cells, the potential role of PD-L1 in tumor propagation suggest a new therapeutic target for preventing glioma infiltration and recurrence.
AB - Infiltration is the main cause of death of malignant glioma patients. However, the mechanisms of the infiltration in the development of brain cancer (glioblastoma multiforme) are not completely understood. Here, we hypothesized that, in the development of human brain cancer, infiltration is primarily due to differentiated cancer cells and that the cell surface molecule programmed death-ligand 1 (PD-L1) may play an important role in brain tumor infiltration. PD-L1 is highly expressed in differentiated glioma cells in comparison to undifferentiated ones. As PD-L1 has both pro-survival and immunoinhibitory functions in tumor cells, the potential role of PD-L1 in tumor propagation suggest a new therapeutic target for preventing glioma infiltration and recurrence.
UR - http://www.scopus.com/inward/record.url?scp=84942833891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942833891&partnerID=8YFLogxK
U2 - 10.1016/j.mehy.2015.04.009
DO - 10.1016/j.mehy.2015.04.009
M3 - Article
VL - 85
SP - 127
EP - 129
JO - Medical Hypotheses
JF - Medical Hypotheses
SN - 0306-9877
IS - 2
ER -